{"created":"2023-07-27T06:31:53.220008+00:00","id":17480,"links":{},"metadata":{"_buckets":{"deposit":"f397f321-e361-4b44-a09d-b17d68ce627f"},"_deposit":{"created_by":3,"id":"17480","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"17480"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00017480","sets":["1132:1137:1270:1353"]},"author_link":["31091"],"item_7_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1996-10-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"586","bibliographicPageStart":"580","bibliographicVolumeNumber":"105","bibliographic_titles":[{"bibliographic_title":"金沢大学十全医学会雑誌"}]}]},"item_7_description_16":{"attribute_name":"その他の識別子","attribute_value_mlt":[{"subitem_description":"1997106321","subitem_description_type":"Other"}]},"item_7_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"1)遺伝子直接導入法により,骨格筋のDNA取り込み機構に対する阻害因子の研究を行った.多価陰イオン,多価陽イオン両者に外来遺伝子導入阻害作用を認めた.ヘパリンとプラスミドDNAは共に多価陰イオンの巨大分子であり,高濃度のヘパリンがDNAの細胞内取り込み系や輸送系において競合している可能性が考えられた. 2)ポリ-L-リジン及び高濃度ヒストンをはじめ陽性荷電を有する脂質においても導入が阻害されることより,DNAの骨格筋への導入には,その陰性荷電が重要と考えられた. 3)蛋白分解酵素のトリプシン及びDNA分解酵素の混入のないプロテナーゼKに強い導入阻害が認められたことより,遺伝子導入の阻害は蛋白分解酵素に混入するDNA分解酵素によるDNAの分解がその主因とは考えられず,筋のDNA取り込みに筋膜,又は細胞外の蛋白質が重要な役割を果たしていることが予想された","subitem_description_type":"Abstract"}]},"item_7_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学 医 神経内科","subitem_description_type":"Other"}]},"item_7_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"金沢大学十全医学会"}]},"item_7_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00044397","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022-7226","subitem_source_identifier_type":"ISSN"}]},"item_7_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"土井, 建朗"}],"nameIdentifiers":[{"nameIdentifier":"31091","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-04"}],"displaytype":"detail","filename":"AN00044397-105-055.pdf","filesize":[{"value":"1.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AN00044397-105-055.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/17480/files/AN00044397-105-055.pdf"},"version_id":"139d31b8-a672-4841-bc5a-dee3608e5ccd"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"陰イオン","subitem_subject_scheme":"Other"},{"subitem_subject":"陽イオン","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝子導入","subitem_subject_scheme":"Other"},{"subitem_subject":"ラット","subitem_subject_scheme":"Other"},{"subitem_subject":"骨格筋","subitem_subject_scheme":"Other"},{"subitem_subject":"ラット","subitem_subject_scheme":"Other"},{"subitem_subject":"動物","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ラット骨格筋遺伝子直接導入法における多価陽イオン,多価陰イオンの影響に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ラット骨格筋遺伝子直接導入法における多価陽イオン,多価陰イオンの影響に関する研究"}]},"item_type_id":"7","owner":"3","path":["1353"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-04"},"publish_date":"2017-10-04","publish_status":"0","recid":"17480","relation_version_is_last":true,"title":["ラット骨格筋遺伝子直接導入法における多価陽イオン,多価陰イオンの影響に関する研究"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:02:44.497340+00:00"}