{"created":"2023-07-27T06:31:53.920053+00:00","id":17496,"links":{},"metadata":{"_buckets":{"deposit":"333f64d7-6557-4471-a8f9-64489ac1c2d6"},"_deposit":{"created_by":3,"id":"17496","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"17496"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00017496","sets":["1132:1137:1270:1354"]},"author_link":["31104"],"item_7_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1996-08-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"568","bibliographicPageStart":"551","bibliographicVolumeNumber":"105","bibliographic_titles":[{"bibliographic_title":"金沢大学十全医学会雑誌"}]}]},"item_7_description_16":{"attribute_name":"その他の識別子","attribute_value_mlt":[{"subitem_description":"1997080237","subitem_description_type":"Other"}]},"item_7_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"原発性肺癌215例を対象に,術前化学療法の投与法別に3治療群に分け,抗Fasモノクローナル抗体を用い,Fas抗原の発現率を検討した. 1)術前無治療群のFas抗原発現率は46.3%, BAI群61.1%, IT群70%と術前化学療法群が有意に高率であった.Fas抗原発現量を表すCYTOADに関しても,術前無治療群0.259±0.051, BAI群0.280±0.059, IT群0.300±0.052と有意差で術前化学療法群が高値を示した. 2)Fas抗原はBAI群において,制癌剤の投与薬剤数が増すごとに発現率が高くなる傾向を示し,CYTOADは1剤群0.251±0.042, 2剤(及び3剤)群0.296±0.056, 4剤群0.304±0.073で多剤投与が有意に高値を示した.IT群では,投与回数に比例し,Fas抗原の高率,CYTOADが高値となる傾向を認めた. 3)術前無治療群と異なり,術前化学療法群(BAI群とIT群)のFas抗原陽性例はFas抗原陰性例より有意に予後が良好であった","subitem_description_type":"Abstract"}]},"item_7_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学 医 第1外科","subitem_description_type":"Other"}]},"item_7_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"金沢大学十全医学会"}]},"item_7_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00044397","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022-7226","subitem_source_identifier_type":"ISSN"}]},"item_7_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"疋島, 一徳"}],"nameIdentifiers":[{"nameIdentifier":"31104","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-04"}],"displaytype":"detail","filename":"AN00044397-105-051.pdf","filesize":[{"value":"4.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AN00044397-105-051.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/17496/files/AN00044397-105-051.pdf"},"version_id":"b6cca597-be2f-422e-8e88-9c0cde6a615a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"外科手術","subitem_subject_scheme":"Other"},{"subitem_subject":"研究","subitem_subject_scheme":"Other"},{"subitem_subject":"肺腫瘍(悪性,併用療法,免疫学)","subitem_subject_scheme":"Other"},{"subitem_subject":"免疫組織化学","subitem_subject_scheme":"Other"},{"subitem_subject":"薬物療法","subitem_subject_scheme":"Other"},{"subitem_subject":"Fas抗原","subitem_subject_scheme":"Other"},{"subitem_subject":"アジュバント化学療法","subitem_subject_scheme":"Other"},{"subitem_subject":"アポトーシス","subitem_subject_scheme":"Other"},{"subitem_subject":"ヒト","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"肺癌手術の術前化学療法におけるFas抗原発現とアポトーシス発現に関する免疫組織化学的研究　CAS 200による解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"肺癌手術の術前化学療法におけるFas抗原発現とアポトーシス発現に関する免疫組織化学的研究　CAS 200による解析"}]},"item_type_id":"7","owner":"3","path":["1354"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-04"},"publish_date":"2017-10-04","publish_status":"0","recid":"17496","relation_version_is_last":true,"title":["肺癌手術の術前化学療法におけるFas抗原発現とアポトーシス発現に関する免疫組織化学的研究　CAS 200による解析"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:02:31.661702+00:00"}