{"created":"2023-07-27T06:31:54.671935+00:00","id":17513,"links":{},"metadata":{"_buckets":{"deposit":"5c9c358a-4783-4616-846f-6b3bfdc3e02e"},"_deposit":{"created_by":3,"id":"17513","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"17513"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00017513","sets":["1132:1137:1270:1356"]},"author_link":["31116"],"item_7_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1996-04-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"248","bibliographicPageStart":"239","bibliographicVolumeNumber":"105","bibliographic_titles":[{"bibliographic_title":"金沢大学十全医学会雑誌"}]}]},"item_7_description_16":{"attribute_name":"その他の識別子","attribute_value_mlt":[{"subitem_description":"1997010663","subitem_description_type":"Other"}]},"item_7_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"麻酔下の雄性Sprague-Dawley系ラットにアデノシンA1受容体拮抗薬,FK838を投与した. 1)FK838を持続静注すると,投与初期に軽度のGFRの増加を認めた以外,MBPならびに腎血行動態は不変であった.UV, UNaV, FENaは著しく増加し,水・Na利尿がみられた. 2)FK838の持続静注により,係蹄灌流によるEPFRの変化率は小となり,これにより評価したTGF機構の反応性は抑制された. 3)10-7～10-5MのFK838でヘンレ係蹄を微小灌流したところ,TGF機構は濃度依存性に抑制された. 4)プロベネシドを持続静注すると,FK838の水・Na利尿作用は増強したが,TGF機構はFK838単独静注時と同程度に抑制された.プロベネシドの併用により,FK838の血漿中濃度は上昇したが,尿中排泄量は影響を受けなかった.以上より,FK838は,血管内及び尿細管腔内投与のいずれによってもTGF機構を抑制する","subitem_description_type":"Abstract"}]},"item_7_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学 医 第1内科","subitem_description_type":"Other"}]},"item_7_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"金沢大学十全医学会"}]},"item_7_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00044397","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022-7226","subitem_source_identifier_type":"ISSN"}]},"item_7_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"韓, 文華"}],"nameIdentifiers":[{"nameIdentifier":"31116","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-04"}],"displaytype":"detail","filename":"AN00044397-105-024.pdf","filesize":[{"value":"1.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AN00044397-105-024.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/17513/files/AN00044397-105-024.pdf"},"version_id":"8ab0a632-a024-4ebb-8142-d62e3b6f87b2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Adenosine","subitem_subject_scheme":"Other"},{"subitem_subject":"フィードバック","subitem_subject_scheme":"Other"},{"subitem_subject":"腎糸球体","subitem_subject_scheme":"Other"},{"subitem_subject":"Purinergic Receptors(拮抗物質・阻害物質)","subitem_subject_scheme":"Other"},{"subitem_subject":"腎循環","subitem_subject_scheme":"Other"},{"subitem_subject":"尿細管","subitem_subject_scheme":"Other"},{"subitem_subject":"微小循環","subitem_subject_scheme":"Other"},{"subitem_subject":"Purinergic P1 Receptors","subitem_subject_scheme":"Other"},{"subitem_subject":"ラット","subitem_subject_scheme":"Other"},{"subitem_subject":"動物","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"アデノシンA1受容体遮断の腎微小循環と尿細管糸球体フィードバック機構に及ぼす影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"アデノシンA1受容体遮断の腎微小循環と尿細管糸球体フィードバック機構に及ぼす影響"}]},"item_type_id":"7","owner":"3","path":["1356"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-04"},"publish_date":"2017-10-04","publish_status":"0","recid":"17513","relation_version_is_last":true,"title":["アデノシンA1受容体遮断の腎微小循環と尿細管糸球体フィードバック機構に及ぼす影響"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:02:15.195414+00:00"}