{"created":"2023-07-27T06:31:54.714043+00:00","id":17514,"links":{},"metadata":{"_buckets":{"deposit":"37da27ac-0171-48bf-9182-1a7e5c9cccf9"},"_deposit":{"created_by":3,"id":"17514","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"17514"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00017514","sets":["1132:1137:1270:1356"]},"author_link":["31117"],"item_7_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1996-04-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"256","bibliographicPageStart":"249","bibliographicVolumeNumber":"105","bibliographic_titles":[{"bibliographic_title":"金沢大学十全医学会雑誌"}]}]},"item_7_description_16":{"attribute_name":"その他の識別子","attribute_value_mlt":[{"subitem_description":"1997002331","subitem_description_type":"Other"}]},"item_7_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"1)p53遺伝子の転写活性化はアポトーシス誘導因子による刺激により,未刺激例と比べて約2～9倍に上昇した.過酸化水素では約6倍,フルオロウラシルでは約9倍まで転写活性化が上昇した. 2)p53遺伝子のほぼ-70～-40bpまでのプロモーター領域に変異を導入すると,変異を導入しない例と比べ,過酸化水素によるp53遺伝子の転写活性化はその上昇が抑制された. 3)過酸化水素及びフルオロウラシル双方によるp53遺伝子の転写活性化は,bcl-2により減少したが,抗酸化剤であるNACでは過酸化水素による転写活性のみが減少し,α-トコフェロールや抗酸化酵素であるGSHPX, Ref-1では双方とも減少しなかった. 4)-70～-46bpまでのp53プロモーター領域の過酸化水素による転写活性化は,bcl-2により減少したが,GSHPX, Ref-1では減少しなかった","subitem_description_type":"Abstract"}]},"item_7_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学 医 第1外科","subitem_description_type":"Other"}]},"item_7_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"金沢大学十全医学会"}]},"item_7_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00044397","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022-7226","subitem_source_identifier_type":"ISSN"}]},"item_7_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"呉, 哲彦"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-04"}],"displaytype":"detail","filename":"AN00044397-105-025.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AN00044397-105-025.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/17514/files/AN00044397-105-025.pdf"},"version_id":"9482404f-cd8e-4cd5-9a46-99df2ae6c2f9"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"遺伝子","subitem_subject_scheme":"Other"},{"subitem_subject":"p53遺伝子","subitem_subject_scheme":"Other"},{"subitem_subject":"研究","subitem_subject_scheme":"Other"},{"subitem_subject":"bcl-2癌原遺伝子蛋白質","subitem_subject_scheme":"Other"},{"subitem_subject":"転写活性化","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"p53遺伝子転写活性化に対するbcl-2の影響についての基礎的研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"p53遺伝子転写活性化に対するbcl-2の影響についての基礎的研究"}]},"item_type_id":"7","owner":"3","path":["1356"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-04"},"publish_date":"2017-10-04","publish_status":"0","recid":"17514","relation_version_is_last":true,"title":["p53遺伝子転写活性化に対するbcl-2の影響についての基礎的研究"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:02:14.369280+00:00"}