{"created":"2023-07-27T06:31:55.263548+00:00","id":17527,"links":{},"metadata":{"_buckets":{"deposit":"e12b6868-f8ce-4fc1-a2d7-4c30a5e592c8"},"_deposit":{"created_by":3,"id":"17527","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"17527"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00017527","sets":["1132:1137:1270:1357"]},"author_link":["182"],"item_7_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1996-02-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"53","bibliographicPageStart":"39","bibliographicVolumeNumber":"105","bibliographic_titles":[{"bibliographic_title":"金沢大学十全医学会雑誌"}]}]},"item_7_description_16":{"attribute_name":"その他の識別子","attribute_value_mlt":[{"subitem_description":"1996244153","subitem_description_type":"Other"}]},"item_7_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"1)定型的細胆管は,全ての肝胆道型疾患で種々の程度に増生していた.非定型的細胆管は,PBCやPSC等の原発性胆道系疾患及び肝外閉塞性黄疸,アルコール性肝線維症,亜広汎性肝壊死,肝硬変,慢性活動性肝炎例で種々の程度と頻度でみられた. 2)定型的細胆管は胆管上皮固有の表現型を有し,増殖活性の亢進も認めた.小葉間胆管での胆管上皮細胞の増殖活性も亢進していた.つまり,定型的細胆管増生は既存の胆管上皮細胞からの増生による. 3)細胞増殖活性の弱い非定型的細胆管はPBCやPSC等の慢性胆汁うっ滞例でみられ,主として肝細胞の化生による見かけ上の増生である. 4)増殖活性の高い非定型的細胆管は肝外閉塞性黄疸,亜広汎性肝壊死,肝硬変や慢性活動性肝炎例でみられ,不完全な表現型の発現を示す胆管細胞の増殖と考えられ,これら疾患での肝細胞消失に関連する一つの現象と考えられた","subitem_description_type":"Abstract"}]},"item_7_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学 医 第2病理","subitem_description_type":"Other"}]},"item_7_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"金沢大学十全医学会"}]},"item_7_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00044397","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022-7226","subitem_source_identifier_type":"ISSN"}]},"item_7_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"原田, 憲一"}],"nameIdentifiers":[{"nameIdentifier":"182","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30283112","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=30283112"},{"nameIdentifier":"30283112","nameIdentifierScheme":"金沢大学研究者情報","nameIdentifierURI":"http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=30283112"},{"nameIdentifier":"30283112","nameIdentifierScheme":"研究者番号","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000030283112"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-04"}],"displaytype":"detail","filename":"AN00044397-105-005.pdf","filesize":[{"value":"4.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AN00044397-105-005.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/17527/files/AN00044397-105-005.pdf"},"version_id":"4275b4ad-933d-4270-ae02-f86711de2e3e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Transforming Growth Factor Alpha","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞質","subitem_subject_scheme":"Other"},{"subitem_subject":"胆管","subitem_subject_scheme":"Other"},{"subitem_subject":"胆管疾患(病理学)","subitem_subject_scheme":"Other"},{"subitem_subject":"ヒト","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"いわゆる\"細胆管増生\"に関する病理学的研究　細胞形質,細胞動態およびトランスフォーミング増殖因子アルファ発現の解析を中心に","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"いわゆる\"細胆管増生\"に関する病理学的研究　細胞形質,細胞動態およびトランスフォーミング増殖因子アルファ発現の解析を中心に"}]},"item_type_id":"7","owner":"3","path":["1357"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-04"},"publish_date":"2017-10-04","publish_status":"0","recid":"17527","relation_version_is_last":true,"title":["いわゆる\"細胆管増生\"に関する病理学的研究　細胞形質,細胞動態およびトランスフォーミング増殖因子アルファ発現の解析を中心に"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:02:03.293965+00:00"}