{"created":"2023-07-27T06:31:55.474136+00:00","id":17532,"links":{},"metadata":{"_buckets":{"deposit":"3c89af8b-deee-44a6-bb86-153acc16dc83"},"_deposit":{"created_by":3,"id":"17532","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"17532"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00017532","sets":["1132:1137:1270:1357"]},"author_link":["398"],"item_7_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1996-02-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"111","bibliographicPageStart":"102","bibliographicVolumeNumber":"105","bibliographic_titles":[{"bibliographic_title":"金沢大学十全医学会雑誌"}]}]},"item_7_description_16":{"attribute_name":"その他の識別子","attribute_value_mlt":[{"subitem_description":"1996231494","subitem_description_type":"Other"}]},"item_7_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ウサギにプロポフォールを持続静注し,動脈血酸素分圧がプロポフォールの薬物動態とその基剤である脂肪の代謝に与える影響を検討した. 1)高酸素環境ではプロポフォールのクリアランスは空気吸入時と差がなかった.しかし,プロポフォールの基剤として用いられる脂肪のケトン体生成系で処理される比率が高まり,動脈血中のケトン体濃度が大きく上昇する. 2)低酸素環境では,肝でのプロポフォールの除去率の低下と肝血流量の低下の相乗作用により,プロポフォールのクリアランスは約2分の1に減少し,血中濃度は平均で約2倍に上昇した.肝のミトコンドリアは酸素の供給不足により還元状態となり,プロポフォールと脂肪の代謝は抑制されていると考えられた. 3)空気吸入下ではプロポフォールのクリアランスは十分に大きく代謝は早かった.したがって,鎮静度の調節は容易であり,投与中止後の覚醒も迅速であると考えられた","subitem_description_type":"Abstract"}]},"item_7_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学 医 麻酔蘇生","subitem_description_type":"Other"}]},"item_7_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"金沢大学十全医学会"}]},"item_7_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00044397","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022-7226","subitem_source_identifier_type":"ISSN"}]},"item_7_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"坪川, 恒久"}],"nameIdentifiers":[{"nameIdentifier":"398","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"80283109","nameIdentifierScheme":"研究者番号","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000080283109"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-04"}],"displaytype":"detail","filename":"AN00044397-105-010.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AN00044397-105-010.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/17532/files/AN00044397-105-010.pdf"},"version_id":"79523495-e8e6-4ec6-8d3e-cc171ddbc7ab"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Propofol","subitem_subject_scheme":"Other"},{"subitem_subject":"血液循環","subitem_subject_scheme":"Other"},{"subitem_subject":"酸素","subitem_subject_scheme":"Other"},{"subitem_subject":"動脈","subitem_subject_scheme":"Other"},{"subitem_subject":"薬物動態学","subitem_subject_scheme":"Other"},{"subitem_subject":"分圧","subitem_subject_scheme":"Other"},{"subitem_subject":"血液ガス","subitem_subject_scheme":"Other"},{"subitem_subject":"ウサギ","subitem_subject_scheme":"Other"},{"subitem_subject":"動物","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"動脈血酸素分圧がプロポフォール持続投与時の薬物動態に与える影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"動脈血酸素分圧がプロポフォール持続投与時の薬物動態に与える影響"}]},"item_type_id":"7","owner":"3","path":["1357"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-04"},"publish_date":"2017-10-04","publish_status":"0","recid":"17532","relation_version_is_last":true,"title":["動脈血酸素分圧がプロポフォール持続投与時の薬物動態に与える影響"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:01:59.161077+00:00"}