{"created":"2023-07-27T06:31:55.600526+00:00","id":17535,"links":{},"metadata":{"_buckets":{"deposit":"b4899d3f-4cf8-4ab0-9b1e-f253d35003c7"},"_deposit":{"created_by":3,"id":"17535","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"17535"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00017535","sets":["1132:1137:1270:1357"]},"author_link":["31130"],"item_7_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1996-02-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"143","bibliographicPageStart":"136","bibliographicVolumeNumber":"105","bibliographic_titles":[{"bibliographic_title":"金沢大学十全医学会雑誌"}]}]},"item_7_description_16":{"attribute_name":"その他の識別子","attribute_value_mlt":[{"subitem_description":"1996228959","subitem_description_type":"Other"}]},"item_7_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"マウスFM系統のC4遺伝子の-107～-94までにある核因子-1(nuclear factor 1, NF1)の結合のコンセンサス配列を見出し,ゲルシフト法とメチレーション阻害実験により,この配列にHepG2核因子が特異的に結合することを検出した.Slpプロモーターはこのコンセンサス配列中,一塩基置換をもち,NF1類似因子と結合しなかった.試験管内変異法で,C4プロモーターの対応する配列中の1ヶ所をSlp型に置き換えると,chloramphenicol acetyltransferaseアッセイで調べた転写活性はSlpと同レベルまでに低下した.Slpプロモーターの対応する配列中の1ヶ所をC4型に置き換えると,転写活性は一部上昇した.これらの結果から,男性ホルモンのない場合の,C4とSlpプロモーター転写活性の差はNF1類似因子との結合の有無によって規定されていると結論された","subitem_description_type":"Abstract"}]},"item_7_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学がん研究所","subitem_description_type":"Other"}]},"item_7_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"金沢大学十全医学会"}]},"item_7_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00044397","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022-7226","subitem_source_identifier_type":"ISSN"}]},"item_7_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"莫, 如然"}],"nameIdentifiers":[{"nameIdentifier":"31130","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-04"}],"displaytype":"detail","filename":"AN00044397-105-013.pdf","filesize":[{"value":"1.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AN00044397-105-013.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/17535/files/AN00044397-105-013.pdf"},"version_id":"2a483988-dc47-4afb-8c20-04fa18586e3c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"遺伝子","subitem_subject_scheme":"Other"},{"subitem_subject":"補体4","subitem_subject_scheme":"Other"},{"subitem_subject":"転写活性化","subitem_subject_scheme":"Other"},{"subitem_subject":"Nuclear Factor 1(類似体・誘導体)","subitem_subject_scheme":"Other"},{"subitem_subject":"マウス","subitem_subject_scheme":"Other"},{"subitem_subject":"動物","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"核因子-1(NF1)類似因子の補体C4遺伝子の転写活性における役割","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"核因子-1(NF1)類似因子の補体C4遺伝子の転写活性における役割"}]},"item_type_id":"7","owner":"3","path":["1357"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-04"},"publish_date":"2017-10-04","publish_status":"0","recid":"17535","relation_version_is_last":true,"title":["核因子-1(NF1)類似因子の補体C4遺伝子の転写活性における役割"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:01:56.482891+00:00"}