{"created":"2023-07-27T06:31:56.235051+00:00","id":17550,"links":{},"metadata":{"_buckets":{"deposit":"842fc180-bacb-45cf-8ea8-4781feda3ce1"},"_deposit":{"created_by":3,"id":"17550","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"17550"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00017550","sets":["1132:1137:1270:1358"]},"author_link":["658"],"item_7_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1995-12-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"767","bibliographicPageStart":"758","bibliographicVolumeNumber":"104","bibliographic_titles":[{"bibliographic_title":"金沢大学十全医学会雑誌"}]}]},"item_7_description_16":{"attribute_name":"その他の識別子","attribute_value_mlt":[{"subitem_description":"1996188641","subitem_description_type":"Other"}]},"item_7_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"1)フローサイトメトリーにより,好酸球は末梢血中の顆粒球分画におけるCD16抗原陰性細胞群として得られ,二重免疫蛍光染色により,選択的に好酸球表面の抗原発現を解析することが可能であった. 2)IL-5やGM-CSF等の好酸球活性化サイトカインによる全血培養では,末梢血好酸球表面のCD11b抗原発現が極めて早期に増強し,CD69抗原発現が経時的に誘導された. 3)末梢血好酸球表面のCD11b抗原の発現は,アレルギー群において有意に増強しており,末梢血好酸球総数よりも鋭敏な病態評価の指標となると考えた. 4)CD69抗原は通常のアレルギー疾患では末梢血好酸球表面には発現せず,炎症局所に浸潤した好酸球表面に強い誘導が認められた.好酸球増多症の2例では,一部の末梢血好酸球表面にもCD69抗原が強く発現しており,生体内で強い活性化を受けた状態にあることが示唆された","subitem_description_type":"Abstract"}]},"item_7_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学 医 小児科","subitem_description_type":"Other"}]},"item_7_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"金沢大学十全医学会"}]},"item_7_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00044397","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022-7226","subitem_source_identifier_type":"ISSN"}]},"item_7_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"東馬, 智子"}],"nameIdentifiers":[{"nameIdentifier":"658","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"00377392","nameIdentifierScheme":"金沢大学研究者情報","nameIdentifierURI":"http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=00377392"},{"nameIdentifier":"00377392","nameIdentifierScheme":"研究者番号","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000000377392"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-04"}],"displaytype":"detail","filename":"AN00044397-104-073.pdf","filesize":[{"value":"1.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AN00044397-104-073.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/17550/files/AN00044397-104-073.pdf"},"version_id":"b595671c-f6d4-4bf8-89e5-3b9cb9713bf8"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"フローサイトメトリー","subitem_subject_scheme":"Other"},{"subitem_subject":"IgE","subitem_subject_scheme":"Other"},{"subitem_subject":"アレルギー(免疫学)","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝子発現","subitem_subject_scheme":"Other"},{"subitem_subject":"好塩基球","subitem_subject_scheme":"Other"},{"subitem_subject":"表面抗原","subitem_subject_scheme":"Other"},{"subitem_subject":"好酸球(生理学)","subitem_subject_scheme":"Other"},{"subitem_subject":"CD11抗原","subitem_subject_scheme":"Other"},{"subitem_subject":"CD69抗原","subitem_subject_scheme":"Other"},{"subitem_subject":"ヒト","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"アレルギー疾患にみられる好酸球活性化・好塩基球IgE結合状態のフローサイトメトリー法による臨床的評価(I)　アレルギー疾患における好酸球活性化と表面抗原 CD11b, CD69の発現","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"アレルギー疾患にみられる好酸球活性化・好塩基球IgE結合状態のフローサイトメトリー法による臨床的評価(I)　アレルギー疾患における好酸球活性化と表面抗原 CD11b, CD69の発現"}]},"item_type_id":"7","owner":"3","path":["1358"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-04"},"publish_date":"2017-10-04","publish_status":"0","recid":"17550","relation_version_is_last":true,"title":["アレルギー疾患にみられる好酸球活性化・好塩基球IgE結合状態のフローサイトメトリー法による臨床的評価(I)　アレルギー疾患における好酸球活性化と表面抗原 CD11b, CD69の発現"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:01:43.098954+00:00"}