{"created":"2023-07-27T06:31:57.969919+00:00","id":17591,"links":{},"metadata":{"_buckets":{"deposit":"94c86317-9fb9-4e1d-a7a1-ecd237794105"},"_deposit":{"created_by":3,"id":"17591","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"17591"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00017591","sets":["1132:1137:1270:1363"]},"author_link":["31173"],"item_7_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1995-02-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"25","bibliographicPageStart":"15","bibliographicVolumeNumber":"104","bibliographic_titles":[{"bibliographic_title":"金沢大学十全医学会雑誌"}]}]},"item_7_description_16":{"attribute_name":"その他の識別子","attribute_value_mlt":[{"subitem_description":"1996027951","subitem_description_type":"Other"}]},"item_7_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"甲状腺腫瘍のH-,K-,N-ras遺伝子それぞれのコドン12とコドン61の点突然変異の有無をPCR法とスロットブロットハイブリダイゼーション法を使って検討した. 1)新鮮手術標本の良性腫瘍では,濾胞腺腫1例にH-rasコドン61でCAG→CGGの,腺腫様甲状腺腫1例にK-rasコドン12でGGT→GATの点突然変異を認めた. 2)新鮮手術標本の悪性腫瘍では,濾胞癌1例にH-rasコドン61でCAG→CGGの点突然変異を認めたが,乳頭癌と未分化癌ではras遺伝子の変異は検出されなかった. 3)穿刺吸引細胞を用いた方法では,乳頭癌,未分化癌ともras遺伝子の変異は検出されなかった. 4)穿刺吸引細胞と新鮮手術標本の結果を合わせると,良性腫瘍では濾胞腺腫11例中1例に,腺腫様甲状腺腫6例中1例に点突然変異を認めた.悪性腫瘍では濾胞癌1例に点突然変異を認めたのみで,乳頭癌と未分化癌ではras遺伝子の変異は検出されなかった","subitem_description_type":"Abstract"}]},"item_7_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学 医 第1内科","subitem_description_type":"Other"}]},"item_7_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"金沢大学十全医学会"}]},"item_7_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00044397","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022-7226","subitem_source_identifier_type":"ISSN"}]},"item_7_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"早川, 哲雄"}],"nameIdentifiers":[{"nameIdentifier":"31173","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-04"}],"displaytype":"detail","filename":"AN00044397-104-003.pdf","filesize":[{"value":"1.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AN00044397-104-003.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/17591/files/AN00044397-104-003.pdf"},"version_id":"2c043dc0-4c0a-4293-8d7d-9c914d03423e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"遺伝子","subitem_subject_scheme":"Other"},{"subitem_subject":"ras遺伝子","subitem_subject_scheme":"Other"},{"subitem_subject":"吸息","subitem_subject_scheme":"Other"},{"subitem_subject":"甲状腺腫瘍(発生学・遺伝学)","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"穿刺","subitem_subject_scheme":"Other"},{"subitem_subject":"変異","subitem_subject_scheme":"Other"},{"subitem_subject":"ヒト","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"日本人の甲状腺腫瘍におけるras遺伝子点突然変異　穿刺吸引細胞を用いた検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"日本人の甲状腺腫瘍におけるras遺伝子点突然変異　穿刺吸引細胞を用いた検討"}]},"item_type_id":"7","owner":"3","path":["1363"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-04"},"publish_date":"2017-10-04","publish_status":"0","recid":"17591","relation_version_is_last":true,"title":["日本人の甲状腺腫瘍におけるras遺伝子点突然変異　穿刺吸引細胞を用いた検討"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:01:06.113552+00:00"}