{"created":"2023-07-27T06:31:58.137933+00:00","id":17595,"links":{},"metadata":{"_buckets":{"deposit":"9558cf4d-d2d2-4aae-b25f-5acdf3e14d80"},"_deposit":{"created_by":3,"id":"17595","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"17595"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00017595","sets":["1132:1137:1270:1363"]},"author_link":["31176"],"item_7_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1995-02-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"63","bibliographicPageStart":"54","bibliographicVolumeNumber":"104","bibliographic_titles":[{"bibliographic_title":"金沢大学十全医学会雑誌"}]}]},"item_7_description_16":{"attribute_name":"その他の識別子","attribute_value_mlt":[{"subitem_description":"1996026462","subitem_description_type":"Other"}]},"item_7_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"虚血,再灌流障害におけるNF-κBの関与を検討する目的で,IL-6遺伝子を指標にして低酸素化,再酸素化によるNF-κBの活性化を研究した. 1)低酸素化によって,転写因子NF-κB活性化によるIL-6遺伝子の転写活性は経時的に増強し,低酸素開始後5時間では,コントロールに比べ約5倍まで転写活性が増強した. 2)転写因子NF-κBの活性化は再酸素化により元に復した. 3)低酸素化によるNF-κBの活性化は,抗酸化剤であるNAC,トコフェロール,チロシンキナーゼインヒビターであるゲニステインによって抑制された. 4)低酸素化によるNF-κB活性化は,MAPキナーゼファミリーに特異的なフォスファターゼであるCL100の多量発現により抑制されたが,MEK1ドミナントネガティブの多量発現によっては抑制されなかった.以上より,虚血,再灌流障害の一機序として,低酸素化による転写因子NF-κBの活性化の関与が示唆された","subitem_description_type":"Abstract"}]},"item_7_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学 医 第2外科","subitem_description_type":"Other"}]},"item_7_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"金沢大学十全医学会"}]},"item_7_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00044397","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022-7226","subitem_source_identifier_type":"ISSN"}]},"item_7_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"村岡, 恵一"}],"nameIdentifiers":[{"nameIdentifier":"31176","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-04"}],"displaytype":"detail","filename":"AN00044397-104-007.pdf","filesize":[{"value":"1.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AN00044397-104-007.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/17595/files/AN00044397-104-007.pdf"},"version_id":"df5d8240-5212-4104-887e-e9fb8229ac6f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"NF-Kappa B","subitem_subject_scheme":"Other"},{"subitem_subject":"転写因子","subitem_subject_scheme":"Other"},{"subitem_subject":"虚血","subitem_subject_scheme":"Other"},{"subitem_subject":"再灌流損傷","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"虚血,再潅流障害における転写因子NF-κB活性化の関与","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"虚血,再潅流障害における転写因子NF-κB活性化の関与"}]},"item_type_id":"7","owner":"3","path":["1363"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-04"},"publish_date":"2017-10-04","publish_status":"0","recid":"17595","relation_version_is_last":true,"title":["虚血,再潅流障害における転写因子NF-κB活性化の関与"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:01:02.780399+00:00"}