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下垂体腺腫における濾胞星細胞の光顕的，電顕的ならびに免疫組織学的研究
https://doi.org/10.24517/00017872
https://doi.org/10.24517/000178722303af45-1c7b-46b3-a8f8-0100c85d0191
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AN00044397-100-073.pdf (7.8 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-10-04 | |||||
| タイトル | ||||||
| タイトル | 下垂体腺腫における濾胞星細胞の光顕的，電顕的ならびに免疫組織学的研究 | |||||
| タイトル | ||||||
| タイトル | An Ultrastructural and Immunoshistochemical Study of Folliculo-Stellate Cells in Human Pituitary Adenomas | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | folliculo-stellate cell | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | immunohistochemistry | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | pituitary adenoma | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | intermediate filament | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| ID登録 | ||||||
| ID登録 | 10.24517/00017872 | |||||
| ID登録タイプ | JaLC | |||||
| 著者 |
立花, 修
× 立花, 修 |
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| 著者別表示 |
Tachibana, Osamu
× Tachibana, Osamu |
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| 書誌情報 |
金沢大学十全医学会雑誌 巻 100, 号 6, p. 1055-1069, 発行日 1991-12-20 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0022-7226 | |||||
| NCID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00044397 | |||||
| 出版者 | ||||||
| 出版者 | 金沢大学十全医学会 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Folliculo-stellate (FS) cells were studied in 102 human pituitary adenomas by electron microscopy and immunohistochemistry using antibodies to S-100 protein and intermediate filament protein. In most pituitary adenomas, few S-100 protein positive FS cells were found in four of the 54 cases of nonfunctioning adenomas. From among glial fibrillary acidic protein (GFAP), keratin and vimentin, FS cells showed the greatest affinity to anti-vimentin antibodies. Stains for desmin or neurofilaments were always negative. Double staining for GFAP and keratin demonstrated a small number of double-labelled cells, but two types of FS cells were usually positive for either GFAP or keratin. Accordingly, FS cells were grossly subdivided into two types: GFAP-positive cells which might be neuroectodermal or glial in origin and keratin-positive cells which might be of oral ectodermal origin. Ultrastructurally, the follicles contained an abundance of fine granular material intermingled with some cell debris and were surrounded by FS cells. The nuclei of FS cells were ovoid or triangular with a marginal accumulation of heterochromatin. The cytoplasm contained numerous intermediate filaments and free ribosomes but no hormonal granules. There were many microvilli and a few cilia extending the follicles. However, there was no basal lamina at the luminal surface of FS cells. The latter were connected to each other by junctional complexes such as desmosomes, tight junctions or intermediate junctions. In one of the four cases, a new type of intercellular junction was found between FS cells and surrounding adenoma cells. This junction was characterized by 1) the presence of plasmalemmal attachment plaques only in FS cells, 2) the cytoplasmic filaments assembling in parallel to the attachment plaques, 3) the parallel plasma membranes being separated by the intercellular amorphous material and, 4) an intercellular space of approximately 25 nm in width. They were similar to hemidesmosomes which are usually seen at the basal epithelium toward the connective tissue. These hemidesmosomal junctions appear to form between quite different types of cells: one is FS cells with numerous cytoplasmic filaments and the other is surrounding adenoma cells with scarce filaments. The follicles demonstrated ultrastructurally that they contained abundant fine granular material intermingled with cell debris. It is conceivable that FS cells contribute to isolate cell debris from the surrounding adenoma cells. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
