@article{oai:kanazawa-u.repo.nii.ac.jp:00017885,
 author = {Tachibana, Osamu and 立花, 修},
 issue = {6},
 journal = {金沢大学十全医学会雑誌},
 month = {Dec},
 note = {Folliculo-stellate (FS) cells were studied in 102 human pituitary adenomas by electron microscopy and immunohistochemistry using antibodies to S-100 protein and intermediate filament protein. In most pituitary adenomas, few S-100 protein positive FS cells were found in four of the 54 cases of nonfunctioning adenomas. From among glial fibrillary acidic protein (GFAP), keratin and vimentin, FS cells showed the greatest affinity to anti-vimentin antibodies. Stains for desmin or neu­rofilaments were always negative. Double staining for GFAP and keratin demonstrated a small num­ber of double-labelled cells, but two types of FS cells were usually positive for either GFAP or ker­atin. Accordingly, FS cells were grossly subdivided into two types: GFAP-positive cells which might be neuroectodermal or glial in origin and keratin-positive cells which might be of oral ectodermal ori­gin. Ultrastructurally, the follicles contained an abundance of fine granular material intermingled with some cell debris and were surrounded by FS cells. The nuclei of FS cells were ovoid or triangu­lar with a marginal accumulation of heterochromatin. The cytoplasm contained numerous intermediate filaments and free ribosomes but no hormonal granules. There were many microvilli and a few cilia extending the follicles. However, there was no basal lamina at the luminal surface of FS cells. The latter were connected to each other by junctional complexes such as desmosomes, tight junctions or intermediate junctions. In one of the four cases, a new type of intercellular junction was found between FS cells and surrounding adenoma cells. This junction was characterized by 1) the presence of plasmalemmal attachment plaques only in FS cells, 2) the cytoplasmic filaments assembling in parallel to the attachment plaques, 3) the parallel plasma membranes being separated by the intercel­lular amorphous material and, 4) an intercellular space of approximately 25 nm in width. They were similar to hemidesmosomes which are usually seen at the basal epithelium toward the connective tis­sue. These hemidesmosomal junctions appear to form between quite different types of cells: one is FS cells with numerous cytoplasmic filaments and the other is surrounding adenoma cells with scarce filaments. The follicles demonstrated ultrastructurally that they contained abundant fine granular material intermingled with cell debris. It is conceivable that FS cells contribute to isolate cell debris from the surrounding adenoma cells.},
 pages = {1055--1069},
 title = {下垂体腺腫における濾胞星細胞の光顕的，電顕的ならびに免疫組織学的研究},
 volume = {100},
 year = {1991}
}