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肺水腫液がサーファクタント活性を介して換気能におよぼす影響－ウサギ未熟胎仔による検討－
https://doi.org/10.24517/00017873
https://doi.org/10.24517/00017873084f1528-1b2a-46ca-96b6-6b91b6a434d3
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AN00044397-100-074.pdf (1.5 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-10-04 | |||||
| タイトル | ||||||
| タイトル | 肺水腫液がサーファクタント活性を介して換気能におよぼす影響－ウサギ未熟胎仔による検討－ | |||||
| タイトル | ||||||
| タイトル | The Effects of Pulmonary Edema Fluid on Respiratory Mechanics through Changing Surfactant Activity : Evaluation with Immature Newborn Rabbits | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | lung surfactant | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | pulmonary edema fluid | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | protein | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | immature newborn rabbit | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| ID登録 | ||||||
| ID登録 | 10.24517/00017873 | |||||
| ID登録タイプ | JaLC | |||||
| 著者 |
新多, 恵子
× 新多, 恵子 |
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| 著者別表示 |
Nitta, Keiko
× Nitta, Keiko |
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| 書誌情報 |
金沢大学十全医学会雑誌 巻 100, 号 6, p. 1070-1084, 発行日 1991-12-20 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0022-7226 | |||||
| NCID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00044397 | |||||
| 出版者 | ||||||
| 出版者 | 金沢大学十全医学会 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To examine the effects that pulmonary edema fluid exerts on respiratory mechanics through changing surfactant activity, a modified natural surfactant (Surfactant CK, S-CK) was suspended at a concentration of 50 mg/m1 in physiological saline or in 2.5～10 times condensed pulmonary edema fluid, which had been obtained from the airways of adult rabbits suffering from oxygen poisoning. The test suspensions were instilled into the lungs of immature newborn rabbits which had been delivered by hysterotomy at 27 days gestational age (term=31 days) and were lacking their own surfactant. Under pentobarbital anesthesia and artificial ventilation with 25 cm H2O peak inspiratory pressure, the immature animals which had not been dosed into the lungs (control group) showed less than 5 ml/kg of tidal volume. In contrast, the animals receiving Surfactant CK in physiological saline (Sonly group) exhibited 25.4士1.7 ml/kg (mean土SEM) of tidal volume (p<0.05 vs control group) under the same artificial ventilation. Meanwhile, in the animals receiving Surfactant CK in 10 times condensed edema fluid, i.e., a mixture containing edema fluid protein(P）and the surfactant (S) with a ratio(P/S ratio) of 11.2, the tidal volume was 12.0士2.3 ml/kg, which is significantly smaller than that of the S-only group. But, in the animals receiving Surfactant CK in 2.5 or 5 times condensed edema fluid(P／S ratio=2.8 or 5.6), the tidal volumes were no different from those of the S-only group. Even with 10 times condensed edema fluid, when P/S ratio was reduced to 5.6 by doubling the surfactant concentration (100 mg/ml), decrease of the tidal volume was not observed. Animals that received Surfactant CK in 420 mg/ml albumin solution, which is the same concentration existing in 10 times condensed edema fluid, showed a tidal volume that was as small as in the condensed edema fluid. In animals receiving Surfactant CK in 24 mg/ml fibrinogen solution, that is the same concentration existing in 10 times condensed plasma, the tidal volume was 18.1士3.0ml/kg (p<0.05 vs S-only group). From these results, it was concluded that respiratory mechanics could be impaired by pulmonary edema fluid through the surfactant inhibitory effect when the P/S ratio increases to over 11.2, and that albumin might be playing a great part in the surfactant inhibitory effect of the pulmonary edema fluid. It was considered that fibrinogen might also have an inhibitory effect. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
