{"created":"2023-07-27T06:32:10.654454+00:00","id":17888,"links":{},"metadata":{"_buckets":{"deposit":"a0f99fc3-2bc0-41e6-a391-92c6b5b21380"},"_deposit":{"created_by":3,"id":"17888","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"17888"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00017888","sets":["1132:1137:1270:1382"]},"author_link":["112338","31424"],"item_7_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1991-12-20","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"1112","bibliographicPageStart":"1102","bibliographicVolumeNumber":"100","bibliographic_titles":[{"bibliographic_title":"金沢大学十全医学会雑誌"}]}]},"item_7_creator_34":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nomura, Yoshiaki"}],"nameIdentifiers":[{}]}]},"item_7_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"It is widely known that volatile anesthetics enhance the potency of muscle relaxants. In this study, the effects of halothane and enflurane on neuromuscular block, induced by vecuronium bro­mide (VB) were examined in vitro. Isolated rat phrenic nerve-hemidiaphragm preparations were sus­pended in baths filled with Krebs' solution, bubbled with a carrier gas (95% 0叶5%CO2) and kept at 37℃by warmed water. The phrenic nerve was stimulated every 20 sec with supramaximal 0.2 msec square wave impulses delivered in a train-of-four stimulation patterns at 2 Hz for 2 sec each. With the above setup, the height of the first twitch in each train (ST), and the ratio of the fourth twitch (T4) to ST (train-of-four ratio, TOFR, T4/ST) were recorded. In the control group, only the carrier gas was bubbled for 30 min, and VB was added to the bath using the cumulative dose method. In the halothane and enflurane groups, 1 % or 2% of the anesthetics were added in the carrier gas which was bubbled into the bath through the vaporizers. After 30 min, VB was then added by the same method as in the control group. A dose-response curve was obtained from each preparation, and ST-ED50 and ST-ED90 (concentrations of VB which depresses twitch height by 50% and 90%, respectively) were compared between groups. ST-ED50 and ST-ED90 of the control group were 3.00土0.2511. g/ml (Mean 土SD)and 4.74士0.33µ g/ml, respectively. Those of the 1 % halothane group decreased 63% and 72% of the control group (p<0.01), and those of the 2% halothane group to 43% and 39% (p<0.01). Similarly, ST-ED50 and ST-ED90 of the 1 % enflurane group were 50% and 58% of the control group (p<0.01), and those of the 2% enflurane group 35% and 39% (p<0.01). TOFR-ED50 and TOFR-ED9o (concentration of VB which caused 50% and 90% decrease in TOFR) of the control group were 2.61 土0.25µ g/ml and 2.01士0.38µ g/ml, respectively. Those of the 1 % halothane group decreased to　63% and 67% of the control group (p<0.01), and those of the 2% halothane group to 37% and 43% (p<0.01)．Likewise, the TOFR-ED5oand TOFR-ED90 0fthe 1% enflurane group were 58% and 68% ;f the control group (p<0.01), and those of the 2% enflurane group 42% and 49% (p<0.01). The results indicate that halothane and enflurane enhance the neuromuscular block induced by VB, and furthermore, suggest that the effects of volatile anesthetics might be mediated by both pre-and post- synaptic inhibition. ","subitem_description_type":"Abstract"}]},"item_7_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00017875","subitem_identifier_reg_type":"JaLC"}]},"item_7_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"金沢大学十全医学会"}]},"item_7_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00044397","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022-7226","subitem_source_identifier_type":"ISSN"}]},"item_7_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"野村, 良明"}],"nameIdentifiers":[{"nameIdentifier":"31424","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-04"}],"displaytype":"detail","filename":"AN00044397-100-076.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"AN00044397-100-076.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/17888/files/AN00044397-100-076.pdf"},"version_id":"2d1e2689-5034-4397-8e14-ce858f80ed87"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ハロタン","subitem_subject_scheme":"Other"},{"subitem_subject":"エンフルラン","subitem_subject_scheme":"Other"},{"subitem_subject":"臭化ベクロニウム","subitem_subject_scheme":"Other"},{"subitem_subject":"神経筋伝達","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"臭化ベクロニウムの筋弛緩作用に及ぼす各種吸入麻酔薬の影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"臭化ベクロニウムの筋弛緩作用に及ぼす各種吸入麻酔薬の影響"},{"subitem_title":"Effects of Volatile Anesthetics on Neuromuscular Block Induced by Vecuronium Bromide","subitem_title_language":"en"}]},"item_type_id":"7","owner":"3","path":["1382"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-04"},"publish_date":"2017-10-04","publish_status":"0","recid":"17888","relation_version_is_last":true,"title":["臭化ベクロニウムの筋弛緩作用に及ぼす各種吸入麻酔薬の影響"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T09:09:03.858280+00:00"}