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臭化パンクロニウムの筋弛緩作用に対する各種吸入麻酔薬の増強効果
https://doi.org/10.24517/00017877
https://doi.org/10.24517/00017877dea0505c-8ac1-4feb-bf1c-0b5a8522190d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AN00044397-100-078.pdf (1.3 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-10-04 | |||||
| タイトル | ||||||
| タイトル | 臭化パンクロニウムの筋弛緩作用に対する各種吸入麻酔薬の増強効果 | |||||
| タイトル | ||||||
| タイトル | Potentiations of Inhalation Anesthetics on Neuromuscular Block Induced by Pancuronium Bromide | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | isoflurane | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | sevoflurane | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | pancuronium bromide | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | end-plate | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| ID登録 | ||||||
| ID登録 | 10.24517/00017877 | |||||
| ID登録タイプ | JaLC | |||||
| 著者 |
塗谷, 栄治
× 塗谷, 栄治 |
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| 著者別表示 |
Nuriya, Eiji
× Nuriya, Eiji |
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| 書誌情報 |
金沢大学十全医学会雑誌 巻 100, 号 6, p. 1128-1139, 発行日 1991-12-20 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0022-7226 | |||||
| NCID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00044397 | |||||
| 出版者 | ||||||
| 出版者 | 金沢大学十全医学会 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The influence of isoflurane and sevoflurane on neuromuscular block, induced by pancuronium bromide(PB) were investigated in vitro using Sprague-Dawley rat phrenic nervehemidiaphragm preparations. The preparation was suspended in modified Krebs' solution aerated with mixture gas of 95% 02 and 5% CO2. The phrenic nerve was stimulated by a train-of-four supramaximal square wave impulses of 0.2 msec duration at 2Hz every 12 second. Single twitch tension (ST) which is at the height of the first response, and train-of-four ratio (TOFR) which is a ratio of the fourth to first twitch height, were measured. The preparations were suspended in the solutions aerated with the gas mixture containing no anesthetic (control group, n=8), isoflurane (isoflurane group, n=24), or sevoflurane (sevoflurane group, n=24). Each anesthetic group was divided into three subgroups according to the concentrations corresponding to 0.5, 1.0, and 1.5 minimum alveolar concentration (MAC). The concentrations of PB causing 50% and 90% depression of ST (ST-ED50 and ST-ED90) and TOFR (TOFR-ED50 and TOFR-ED90）were determined in each preparation by the dose response curve based on a cumulative dose response method. Values of ST-ED50 in the isoflurane group were 68, 45 and 33% of that (2.17土0.09 µ M, mean土SD) in the control group at 0.5, 1.0 and 1.5 MAC, respectively (p<0.01 vs. control). Similarly, the values in the sevoflurane group were 73, 52 and 39% at 0.5, 1.0 and 1.5 MAC, respectively (p<0.01 vs. control). Although both anesthetics reduced dose-dependently ST-ED50, the values in the isoflurane group at 1.0 MAC and 1.5MAC were significantly lower than those in the sevoflurane group (p<0.05). Similar results were also obtained in ST-ED90 between both anesthetics. Values of TOFR-ED50 in the isoflurane group were 76, 56, and 41 % of that (2.20土0.09µ M) in the control at 0.5, 1.0 and 1.5 MAC, respectively. Similarly, the values of the sevoflurane group were 84, 58 and 45% at 0.5, 1.0 and 1.5 MAC, respectively. The findings on TOFR-ED90 were similar to the above. Thus, both anesthetics also reduced dose-dependently and significantly TOFR (p<0.01). In addition, the regression line between the depression percentages of ST and TOFR shifted toward the right, when both anesthetics were added. This means that the degree of depression in ST became greater than that in TOFR. These data suggest that isoflurane and sevoflurane potentiate significantly the neuromuscular block induced by pancuronium. The potentiating effect of isoflurane is stronger than that of sevoflurane in this model. These results indicate that the site of action of the these anesthetics might be at both a pre- and post-synaptic site at the neuromuscular junction, and the influence might be stronger at post-synaptic site. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
