@article{oai:kanazawa-u.repo.nii.ac.jp:00026584,
 author = {Ichimatsu, Daisuke and Nomura, Masaaki and Nakamura, Seiji and Moritani, Syuzo and Yokogawa, Koichi and Kobayashi, Shinjiro and Nishioka, Tatsuo and Miyamoto, Kenichi},
 issue = {6},
 journal = {Molecular Carcinogenesis},
 month = {Jun},
 note = {We found that quercetin, myricetin, quercetagetin, fisetin, (-)-epigallocatechin gallate (EGCG), and theaflavins, among 24 flavonoids examined, markedly inhibited epidermal growth factor (EGF)-induced cell transformation of mouse epidermal JB6 Cl 41 cells. The six flavonoids suppressed the EGF-induced activation of activator protein 1 (AP-1). In addition, myricetin, quercetagetin, EGCG, and theaflavins directly inhibited EGF-induced phosphatidylinositol 3-kinase (PI3K) activation. The important structural features of flavonoids for cell transformation-inhibitory activity are 3′- and 4′-OH on the B-ring, 3-OH on the C-ring, C2=C3 double bond in the C-ring, and the phenylchromone (C6-C5-C6) skeleton in the flavonols, and the galloyl group in EGCG and theaflavins. Our results provide new insight into possible mechanisms of the anti-carcinogenic effects of flavonoids, and could help to provide a basis for the design of novel cancer chemopreventive agents. © 2007 Wiley-Liss, Inc., 金沢大学医学部附属病院薬剤部},
 pages = {436--445},
 title = {Structure-activity relationship of flavonoids for inhibition of epidermal growth factor-induced transformation of JB6 CI 41 cells},
 volume = {46},
 year = {2007}
}