{"created":"2023-07-27T06:38:29.996669+00:00","id":26584,"links":{},"metadata":{"_buckets":{"deposit":"bd4a5529-a6a0-4cfb-8f59-55d592ca5104"},"_deposit":{"created_by":3,"id":"26584","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"26584"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00026584","sets":["1761:1762:1763"]},"author_link":["22059","22233","44558","44559","44562","26700","44560","44561"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-06-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"445","bibliographicPageStart":"436","bibliographicVolumeNumber":"46","bibliographic_titles":[{"bibliographic_title":"Molecular Carcinogenesis"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We found that quercetin, myricetin, quercetagetin, fisetin, (-)-epigallocatechin gallate (EGCG), and theaflavins, among 24 flavonoids examined, markedly inhibited epidermal growth factor (EGF)-induced cell transformation of mouse epidermal JB6 Cl 41 cells. The six flavonoids suppressed the EGF-induced activation of activator protein 1 (AP-1). In addition, myricetin, quercetagetin, EGCG, and theaflavins directly inhibited EGF-induced phosphatidylinositol 3-kinase (PI3K) activation. The important structural features of flavonoids for cell transformation-inhibitory activity are 3′- and 4′-OH on the B-ring, 3-OH on the C-ring, C2=C3 double bond in the C-ring, and the phenylchromone (C6-C5-C6) skeleton in the flavonols, and the galloyl group in EGCG and theaflavins. Our results provide new insight into possible mechanisms of the anti-carcinogenic effects of flavonoids, and could help to provide a basis for the design of novel cancer chemopreventive agents. © 2007 Wiley-Liss, Inc.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医学部附属病院薬剤部","subitem_description_type":"Other"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"John Wiley & Sons"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1002/mc.20292","subitem_relation_type_select":"DOI"}}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0899-1987","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ichimatsu, Daisuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nomura, Masaaki"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Nakamura, Seiji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Moritani, Syuzo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yokogawa, Koichi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Kobayashi, Shinjiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nishioka, Tatsuo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyamoto, Kenichi"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"HO-PR-MIYAMOTO-K-436.pdf","filesize":[{"value":"404.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HO-PR-MIYAMOTO-K-436.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/26584/files/HO-PR-MIYAMOTO-K-436.pdf"},"version_id":"5a4eb912-d943-48d3-aec1-c274297e5c5d"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Structure-activity relationship of flavonoids for inhibition of epidermal growth factor-induced transformation of JB6 CI 41 cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Structure-activity relationship of flavonoids for inhibition of epidermal growth factor-induced transformation of JB6 CI 41 cells"}]},"item_type_id":"4","owner":"3","path":["1763"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"26584","relation_version_is_last":true,"title":["Structure-activity relationship of flavonoids for inhibition of epidermal growth factor-induced transformation of JB6 CI 41 cells"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-27T21:22:03.855855+00:00"}