{"created":"2023-07-27T06:38:30.126082+00:00","id":26587,"links":{},"metadata":{"_buckets":{"deposit":"50338d12-fe83-497b-b83b-3c42da5dc05c"},"_deposit":{"created_by":3,"id":"26587","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"26587"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00026587","sets":["1761:1762:1763"]},"author_link":["44572","22059","22233","640","22000"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001-01-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"565","bibliographicPageStart":"557","bibliographicVolumeNumber":"121","bibliographic_titles":[{"bibliographic_title":"薬学雑誌"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"This paper described the studies on the mechanism of subcellular distribution of lipophilic weak bases. Although the tissue distribution of basic drugs appeared to decrease with time simply in parallel with their plasma concentration, their subcellular distribution in various tissues exhibited a variety of patterns. Basic drugs were distributed widely in various tissues, but were concentrated in lung granule fraction, where their accumulation was dependent on their lipophilicity and lysosomal uptake. As the plasma concentration of drugs decreased after maximum level, the contribution of lysosomes to their subcellular distribution increased. The uptake of the basic drugs into lysosomes depended both on their intralysosomal pH and on the drug lipophilicity. As the lipophilicity of the basic drugs increased, they accumulated more than the values predicted from the pH-partition theory and raised the intralysosomal pH more potently, probably owing to their binding with lysosomal membranes with or without additional intralysosomal aggregation. These phenomena should be considered as a basis of drug interaction in clinical treatments.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医学部附属病院薬剤部","subitem_description_type":"Other"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本薬学会"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1248/yakushi.121.557","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.jstage.jst.go.jp/article/yakushi/121/7/121_557/_article/-char/ja","subitem_relation_type_select":"URI"}}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0031-6903","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ishizaki, Junko"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Yokogawa, Koichi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Ohkuma, Shoji"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Ichimura, Fujio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyamoto, Kenichi"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"HO-PR-YOKOGWA-K-557.pdf","filesize":[{"value":"692.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HO-PR-YOKOGWA-K-557.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/26587/files/HO-PR-YOKOGWA-K-557.pdf"},"version_id":"cb6938c5-9930-45c6-a140-c56e727a2938"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Studies on the mechanism of subcellular distribution of basic drugs based on their lipophilicity","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Studies on the mechanism of subcellular distribution of basic drugs based on their lipophilicity"},{"subitem_title":"塩基性薬物の脂溶性に基づく細胞内分布機構に関する研究","subitem_title_language":"en"}]},"item_type_id":"4","owner":"3","path":["1763"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"26587","relation_version_is_last":true,"title":["Studies on the mechanism of subcellular distribution of basic drugs based on their lipophilicity"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-27T21:22:00.596504+00:00"}