{"created":"2023-07-27T06:38:30.470350+00:00","id":26595,"links":{},"metadata":{"_buckets":{"deposit":"563a019e-78b4-4000-8e34-0c6e46684d14"},"_deposit":{"created_by":3,"id":"26595","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"26595"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00026595","sets":["1761:1762:1763"]},"author_link":["20357","21465","20177","20582","44597","44598","79","21455"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-05-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"882","bibliographicPageStart":"879","bibliographicVolumeNumber":"80","bibliographic_titles":[{"bibliographic_title":"Journal of Medical Virology"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV) associated malignant tumor. Recently, cidofovir, an anti-viral drug which is an acyclic nucleoside analogue, has been reported to have an anti-tumor potential. Two patients with NPC, who had previously received multi-round therapy, were treated with cidofovir. Cidofovir was topically injected in and around the tumor once every 3 weeks (originally 75 mg/ml sulution, diluted to 15 mg/ml just before injection, 37.5 mg of cidofoviratatime).Tumorgrowth was suppressed for several months around the injection site in each patient. EBV-encoded RNAs in situ hybridization revealed the reduction of the tumor cell population; however, the EBER expression was still maintained in the NPC tumor cells. Although the anti-tumor mechanism remains unclear, these results suggest that cidofovir is actually an effective and safe agent for the treatment of NPC. © 2008 Wiley-Liss, Inc.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院耳鼻咽喉科","subitem_description_type":"Other"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"John Wiley & Sons"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1002/jmv.21165","subitem_relation_type_select":"DOI"}}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA00702400","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0146-6615","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yoshizaki, Tomokazu"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Wakisaka, Naohiro"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Kondo, Satoru"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Murono, Shigeyuki"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Shimizu, Yoshinori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakashima, Masashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsuji, Akira"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Furukawa, Mitsuru"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"HO-PR-YOSHIZAKI-T-879.pdf","filesize":[{"value":"70.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HO-PR-YOSHIZAKI-T-879.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/26595/files/HO-PR-YOSHIZAKI-T-879.pdf"},"version_id":"c1c188c3-9661-4ba4-acd1-0771cb605c69"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Treatment of locally recurrent Epstein-Barr virus-associated nasopharyngeal carcinoma using the anti-viral agent cidofovir","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Treatment of locally recurrent Epstein-Barr virus-associated nasopharyngeal carcinoma using the anti-viral agent cidofovir"}]},"item_type_id":"4","owner":"3","path":["1763"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"26595","relation_version_is_last":true,"title":["Treatment of locally recurrent Epstein-Barr virus-associated nasopharyngeal carcinoma using the anti-viral agent cidofovir"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-27T21:21:54.526109+00:00"}