@article{oai:kanazawa-u.repo.nii.ac.jp:00026610,
 author = {山下, 竜也 and 荒井, 邦明 and 水腰, 英四郎 and 酒井, 佳夫 and 加賀谷, 尚史 and 中本, 安成 and 本多, 政夫 and 和田, 隆志 and 横山, 仁 and 金子, 周一 and Yamashita, Tatsuya and Arai, Kuniaki and Sakai, Akito and Mizukoshi, Eishiro and Sakai, Yoshio and Kagaya, Takashi and Nakamoto, Yasunari and Honda, Masao and Wada, Takashi and Yokoyama, Hitoshi and Kaneko, Shuichi},
 issue = {3},
 journal = {Hepatology Research},
 month = {Nov},
 note = {Purpose: In patients with chronic genotype 1b hepatitis C and a high viral load, the viral load was reduced by double filtration plasmapheresis (DFPP), followed by combined interferon and ribavirin therapy. The safety and virological effects of this treatment method were preliminarily investigated. Methods: In nine patients with chronic hepatitis C, DFPP was performed three times on days 1, 2, and 4, and the administration of interferon and ribavirin was initiated immediately after DFPP on day 1. Result: The HCV RNA was undetectable in all patients after the plasma was passed through a plasma fractionator (second filter) in the DFPP circuit. After 2 weeks, the HCV RNA tended to decrease in the DFPP group more than in the control group (-2.45 ± 1.12 versus -1.57 ± 0.95, P = 0.073). However, this decrease was not attributable to a sustained virological response (SVR) (22.2% versus 18.2%, P = 0.822). Most of the adverse events were caused by the interferon and ribavirin combination therapy. Conclusion: DFPP can be safely performed concomitantly with interferon and ribavirin combination therapy in chronic hepatitis C patients. The combination may contribute to an early virological response. The effect of DFPP on the SVR and its significance remain to be clarified. © 2006 Elsevier Ireland Ltd. All rights reserved., 金沢大学先進予防医学研究センター / 金沢大学医学部附属病院内科},
 pages = {167--175},
 title = {Virological effects and safety of combined double filtration plasmapheresis (DFPP) and interferon therapy in patients with chronic hepatitis C: A preliminary study},
 volume = {36},
 year = {2006}
}