{"created":"2023-07-27T06:38:31.863047+00:00","id":26627,"links":{},"metadata":{"_buckets":{"deposit":"127a6023-cdbd-44cc-b689-edb0f8aad521"},"_deposit":{"created_by":3,"id":"26627","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"26627"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00026627","sets":["1761:1762:1763"]},"author_link":["44705","44707","22059","22233","44708","26700","44706"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-09-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"76","bibliographicPageStart":"67","bibliographicVolumeNumber":"44","bibliographic_titles":[{"bibliographic_title":"Molecular Carcinogenesis"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We found that caffeine significantly inhibited epidermal growth factor (EGF)- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced cell transformation in the JB6 mouse epidermal cell line. The tumor promoter-induced cell transformation was also blocked by treatment with an adenosine A1 receptor antagonist, 8-phenyltheophylline (8-PTH). Caffeine slightly attenuated activation of EGF-induced activator protein 1 (AP-1) activation, which play important roles in cell transformation, but only at the highest concentration examined (1 mM). Interestingly, pretreatment with caffeine suppressed EGF-induced phosphorylation and activation of Akt and ribosomal p70 S6 protein kinase (p70 S6K), a target of Akt, without inhibiting phosphatidylinositol 3-kinase (PI3K) activation. The inhibition of Akt activation of caffeine was not a result of its adenosine receptor antagonism. Because Akt plays a key role in signal transduction pathways leading to cell proliferation and apoptosis, our results provide novel insight into possible mechanisms of the chemotherapeutic effect of caffeine. © 2005 Wiley-Liss, Inc.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医学部附属病院薬剤部","subitem_description_type":"Other"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Wiley-Liss"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1002/mc.20120","subitem_relation_type_select":"DOI"}}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0899-1987","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nomura, Masaaki"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Ichimatsu, Daisuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Moritani, Shuzo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Koyama, Ichiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Dong, Zigang"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yokogawa, Koichi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Miyamoto, Kenichi"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"PH-PR-MIYAMOTO-K-67.pdf","filesize":[{"value":"323.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PH-PR-MIYAMOTO-K-67.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/26627/files/PH-PR-MIYAMOTO-K-67.pdf"},"version_id":"dd9fcec8-5b98-416a-b259-0284c77ba23d"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Inhibition of epidermal growth factor-induced cell transformation and Akt activation by caffeine","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Inhibition of epidermal growth factor-induced cell transformation and Akt activation by caffeine"}]},"item_type_id":"4","owner":"3","path":["1763"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"26627","relation_version_is_last":true,"title":["Inhibition of epidermal growth factor-induced cell transformation and Akt activation by caffeine"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T12:21:47.748181+00:00"}