{"created":"2023-07-27T06:38:32.128032+00:00","id":26633,"links":{},"metadata":{"_buckets":{"deposit":"69f5ab78-08ae-406d-aaef-b42d17ad9cf7"},"_deposit":{"created_by":3,"id":"26633","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"26633"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00026633","sets":["1761:1762:1763"]},"author_link":["304"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-10-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"308","bibliographicPageStart":"300","bibliographicVolumeNumber":"28","bibliographic_titles":[{"bibliographic_title":"Japanese journal of clinical immunology"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Recent studies have revealed that B cells play a critical role in autoimmunity and disease expression through various functions, including autoantibody production, cytokine secretion, antigen presentation, and co-stimulatory effect. Selective targeting of B cells has been recently achieved using a chimeric monoclonal antibody against CD20 (Rituximab). Significant clinical efficacy has been demonstrated in several autoimmune diseases including rheumatoid arthritis and systemic lupus erythematosus by the infusion of this antibody. Rituxumab significantly improves the symptoms during the long period of complete B cell depletion. Understanding the dynamics of B cell involvement in autoimmune diseases will be crucial to the development of B cell-targeted strategies. Conversely, the findings derived from studies of anti-B cell therapy provide us a lot of important clues to clarify the pathogenesis of autoimmune diseases. This review focuses on recent data demonstrating the roles of B cells in autoimmune diseases as well as the current studies concerning the treatment of autoimmune diseases by Rituximab.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医学部附属病院皮膚科","subitem_description_type":"Other"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本臨床免疫学会"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0911-4300","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"長谷川, 稔"}],"nameIdentifiers":[{"nameIdentifier":"304","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50283130","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50283130"},{"nameIdentifier":"50283130","nameIdentifierScheme":"研究者番号","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000050283130"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"ME-PR-HASEGAWA-M-300.pdf","filesize":[{"value":"788.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ME-PR-HASEGAWA-M-300.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/26633/files/ME-PR-HASEGAWA-M-300.pdf"},"version_id":"02b06dae-3528-4fe0-b834-e44a06f55d6f"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"B細胞","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"B細胞"},{"subitem_title":"B lymphocyte","subitem_title_language":"en"}]},"item_type_id":"4","owner":"3","path":["1763"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"26633","relation_version_is_last":true,"title":["B細胞"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-06-25T04:50:50.828736+00:00"}