@article{oai:kanazawa-u.repo.nii.ac.jp:00026664,
 author = {宮本, 謙一 and 涌沢, 伸哉 and 柳岡, 利一 and 越浦, 良三},
 issue = {12},
 journal = {藥學雜誌},
 month = {Dec},
 note = {The effect of six Rauwolfia alkaloids on the growth inhibitory effect of vinblastine (VBL) in rat ascites hepatoma AH66 cells was investigated. When cells were treated with VBL and each alkaloid for 30 min, reserpine, rescinnamine, syrosingopine, and ajmaline markedly potentiated the effect of VBL, but dimethylaminoethylreserplinate hydrochloride (DMAR) and yohimbine did not influence. On the other hand, in the continuous treatment for 2 d, DMAR and yohimbine also potentiated the effect of VBL. All of alkaloids increased the intracellular VBL content. Among these alkaloids, reserpine markedly suppressed the activities of Mg^<2+>ATPase and Ca^<2+>ATPase in the plasma membrane and DMAR suppressed the activities of adenosine triphosphatase (ATPase) except (Na^+-K^+) ATPase. Reserpine and DMAR did not affect the VBL binding to microtubules. Reserpine inhibited the microtubule polymerization by itself and synergistically acted with VBL on microtubules but DMAR did not affect the polymerization and the effect of VBL. From the results, it was indicated that all of Rauwolfia alkaloids suppressed the active extrusion of VBL, increased the intracellular VBL content, and potentiated the effect of VBL on AH66 cells. Moreover, it was suggested that some of alkaloids including reserppine could enhance the effect of VBL even by a short term treatment because of their synergistical interaction with VBL on microtubules., 金沢大学医学部附属病院薬剤部},
 pages = {1295--1300},
 title = {Rauwolfia Alkaloidsによるビンブラスチン増感作用について},
 volume = {104},
 year = {1984}
}