@article{oai:kanazawa-u.repo.nii.ac.jp:00026673,
 author = {中本, 安成 and 稲垣, 豊 and 北野, 善郎 and 荻野, 英朗 and 河合, 博志 and 種井, 政信 and 西村, 浩一 and 松下, 栄紀 and 卜部, 健 and 金子, 周一 and 鵜浦, 雅志 and 小林, 健一},
 issue = {9},
 journal = {Acta Hepatologica Japonica},
 month = {Jan},
 note = {We report a case of chronic active hepatitis type C associated with hyperthyroidism following a long-term interferon therapy. A 49-year-old man, who had received 1,440 ml of blood transfusion for massive bleeding from the gastric ulcer, was diagnosed as posttransfusion hepatitis 40 days later. While antibodies to thyroid microsomal antigen was positive, he was euthyroid state at the onset of hepatitis. A total of 474 MU of recombinant IFNﾎｱ was injected subcutaneously for 12 months. Nine months after the end of the therapy, finger tremor and body weight loss appeared. Laboratory data revealed overt hyperthyroidism. Thyroid stimulating antibodies, TSH receptor antibodies and antinuclear antibodies appeared following interferon therapy, as well as antibodies to thyroid microsomal antigen and islet cell surface antigen, which had been positive since the beginning of the therapy. Recently, various autoimmune responses have been shown to appear in the course of long-term interferon therapy, which will be of great clinical significance in the management of chronic type B and C hepatitis., 金沢大学医学部附属病院内科（旧第一内科）},
 pages = {863--867},
 title = {甲状腺機能亢進症の発症にインターフェロン療法の関与が示唆されたC型慢性活動性肝炎の1例},
 volume = {32},
 year = {1991}
}