{"created":"2023-07-27T06:38:34.368303+00:00","id":26684,"links":{},"metadata":{"_buckets":{"deposit":"4183f49d-f9df-4afb-b920-7cd9d310a27b"},"_deposit":{"created_by":3,"id":"26684","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"26684"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00026684","sets":["1761:1762:1763"]},"author_link":["22059","22233","44933","21465","640","29","44935","26700","44934"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-10-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"1050","bibliographicPageStart":"1042","bibliographicVolumeNumber":"72","bibliographic_titles":[{"bibliographic_title":"Biochemical Pharmacology"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We examined whether the oral bioavailability of cyclosporin A is controlled primarily by P-glycoprotein (P-gp) or CYP3A in the small intestine. In situ loop method was used to evaluate the uptake of cyclosporin A (40 nmol) at the upper and lower intestine of wild-type and mdr1a/1b knockout mice treated or not treated with dexamethasone (75 mg/kg/day, 7 days, i.p.). Expression of CYP3A mRNA in the control group was higher in the upper than the lower intestine, while that of the multidrug resistance-1a (mdr1a) mRNA was in the opposite order. Dexamethasone administration potently induced CYP3A and mdr1a mRNAs in the lower and upper intestine, respectively. At 45 min after cyclosporin A administration into an upper intestinal loop of the control group of wild-type mice, the ratio of residual cyclosporin A to dose did not differ significantly from that of mdr1a/1b knockout mice, whereas in dexamethasone-treated wild-type mice, the residual ratio was increased significantly. The ratio of the cyclosporin A metabolite M17 to cyclosporin A in portal venous blood at an upper intestinal loop of mdr1a/1b knockout mice was much higher than that a lower intestinal loop. The M17/cyclosporin A ratio of portal venous blood at a lower intestinal loop in mdr1a/1b knockout mice was increased significantly by dexamethasone treatment. These results suggest that, under physiological conditions, the oral bioavailability of cyclosporin A is mainly controlled by CYP3A in the upper intestine, rather than liver, but when P-gp is induced by steroid, the intestinal absorption of cyclosporin A may be inhibited. © 2006 Elsevier Inc. All rights reserved.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医学部附属病院薬剤部","subitem_description_type":"Other"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier BV"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.bcp.2006.07.020","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.elsevier.com/locate/issn/00062952","subitem_relation_type_select":"URI"}}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0006-2952","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Jin, Ingji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shimada, Tsutomu"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Yokogawa, Koichi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Nomura, Masaaki"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Ishizaki, Junko"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Piao, Yingshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kato, Yukio"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Tsuji, Akira"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Miyamoto, Kenichi"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"HO-PR-MIYAMOTO-K-04.pdf","filesize":[{"value":"495.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HO-PR-MIYAMOTO-K-04.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/26684/files/HO-PR-MIYAMOTO-K-04.pdf"},"version_id":"4cae8e7d-d2ac-49d0-8052-2585dea4c180"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Site-dependent contributions of P-glycoprotein and CYP3A to cyclosporin A absorption, and effect of dexamethasone in small intestine of mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Site-dependent contributions of P-glycoprotein and CYP3A to cyclosporin A absorption, and effect of dexamethasone in small intestine of mice"}]},"item_type_id":"4","owner":"3","path":["1763"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"26684","relation_version_is_last":true,"title":["Site-dependent contributions of P-glycoprotein and CYP3A to cyclosporin A absorption, and effect of dexamethasone in small intestine of mice"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T12:24:18.222676+00:00"}