{"created":"2023-07-27T06:38:34.630740+00:00","id":26690,"links":{},"metadata":{"_buckets":{"deposit":"5d077a44-5059-4452-8e7d-f23fb18b6a0e"},"_deposit":{"created_by":3,"id":"26690","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"26690"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00026690","sets":["1761:1762:1763"]},"author_link":["31330","44960","110","44962","44963","157","44961","282","44958","496","44959"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-11-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageEnd":"977","bibliographicPageStart":"971","bibliographicVolumeNumber":"41","bibliographic_titles":[{"bibliographic_title":"Oral Oncology"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"There have been reports of strong correlations between poor prognosis in various cancers and concomitant expression of urokinase-type plasminogen activator (uPA) and its surface receptor (uPAR). We and others have previously shown that the uPA system plays a significant role in a subset of head and neck squamous cell carcinoma. In the present study, we found that uPAR is required for invasion and metastasis of highly malignant oral cancer cells (OSC-19). Treating OSC-19 cells with antisense oligonucleotides (AS) targeting uPAR resulted in a dramatic decrease of uPAR mRNA expression. Furthermore, pretreatment with AS or siRNA targeting uPAR inhibited progression of OSC-19 cells in experimental models. These results suggest that overexpression of uPAR increases the invasiveness and metastasis of OSC-19 cells, and that uPAR is a promising therapeutic target for regulation of progression of oral cancer.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医学部附属病院","subitem_description_type":"Other"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.oraloncology.2005.05.013","subitem_relation_type_select":"DOI"}}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1368-8375","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nozaki, Shinichi"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Endo, Yoshio"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Nakahara, Hirokazu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshizawa, Kunio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hashiba, Yukari"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawashiri, Shuichi"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Tanaka, Akira"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakagawa, Kiyomasa"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Matsuoka, Yudai"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kogo, Mikihiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamamoto, Etsuhide"}],"nameIdentifiers":[{},{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"nozaki3.pdf","filesize":[{"value":"827.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"nozaki3.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/26690/files/nozaki3.pdf"},"version_id":"454b69a1-b01e-4903-8053-957895bb17b7"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Inhibition of invasion and metastasis in oral cancer by targeting urokinase-type plasminogen activator receptor","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Inhibition of invasion and metastasis in oral cancer by targeting urokinase-type plasminogen activator receptor"}]},"item_type_id":"4","owner":"3","path":["1763"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"26690","relation_version_is_last":true,"title":["Inhibition of invasion and metastasis in oral cancer by targeting urokinase-type plasminogen activator receptor"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T11:50:07.675900+00:00"}