{"created":"2023-07-27T06:38:35.508539+00:00","id":26710,"links":{},"metadata":{"_buckets":{"deposit":"9fb256df-429d-4d3f-8613-cc1bd6084e5d"},"_deposit":{"created_by":3,"id":"26710","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"26710"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00026710","sets":["1761:1762:1763"]},"author_link":["45033","22059","45032","45034"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1980-03-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"354","bibliographicPageStart":"347","bibliographicVolumeNumber":"100","bibliographic_titles":[{"bibliographic_title":"藥學雜誌"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The pharmacological properties of DL-1-(γ-chloropropyl)-2-chloromethylpiperidine hydrobromide (CAP-2), a new nitrogen mustard type antitumor agent, were investigated in various experimental animals. The LD_<50> value by intraperitoneal single injection of CAP-2 was 60.0 mg/kg for female mice and 65.0 mg/kg for male mice 7 days after injection. Female and male received a maximum tolerated dose of 30 mg/kg and 25 mg/kg, respectively, of CAP-2 intraperitoneally once a day for 7 days. Decrease of spontaneous motalities, mild prolongation of sleeping time, hypothermia, and analgesic action were observed by intraperitoneal injection in mice of a dose of 30 mg/kg of CAP-2,but not at smaller doses. In the isolated large intestine of the guinea pig, a low concentration of CAP-2 caused relaxation and a decrease of activity which was antagonistic for acetylcholine, but not for barium chloride. Intestinal relaxation disappeared and changed to intestinal contraction by the repeated application of CAP-2 (1×10^<-4>g/ml). CAP-2 (1×10^<-4>g/ml) caused intestines relaxed by atropine to contract and increased their activity. This contraction was inhibited by paraverine. In the isolated heart of the frog, CAP-2 showed a negative inotropic action and a concentration of 1×10^<-4>g/ml inhibited the diastric standstill by acetylcholine. CAP-2 did not affect femoral vessel flow in the frog even at a concentration of 3×10^<-2>g/ml. CAP-2 tended to contract the rectus abdominis muscle of the frog. In the rabbit, CAP-2 (1-5mg/kg, i.v.) exhibited a temporary hypotensive action and weak respiratory stimulation. From these results, it was confirmed that CAP-2 has a depressant effect on the central nervous system and an anticholinergic action on the peripheria.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医学部附属病院薬剤部","subitem_description_type":"Other"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本薬学会"}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00284903","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0031-6903","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"山田, 澄"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"越浦, 良三"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"宮本, 謙一"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"早苗, 富士子"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"HO-PR-MIYAMOTO-K-347.pdf","filesize":[{"value":"754.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HO-PR-MIYAMOTO-K-347.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/26710/files/HO-PR-MIYAMOTO-K-347.pdf"},"version_id":"4dd0d4a7-6f13-448d-ab78-9927caeeae07"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"新規抗癌剤DL-1-(γ-Chloropropyl)-2-chloromethylpiperidine Hydrobromideの薬理作用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"新規抗癌剤DL-1-(γ-Chloropropyl)-2-chloromethylpiperidine Hydrobromideの薬理作用"},{"subitem_title":"Pharmacological Studies on DL-1-(γ-Chloropropyl)-2-chloromethylpiperidine Hydrobromide, a New Antitumor Agent","subitem_title_language":"en"}]},"item_type_id":"4","owner":"3","path":["1763"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"26710","relation_version_is_last":true,"title":["新規抗癌剤DL-1-(γ-Chloropropyl)-2-chloromethylpiperidine Hydrobromideの薬理作用"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-27T21:20:17.469902+00:00"}