@article{oai:kanazawa-u.repo.nii.ac.jp:00026750,
 author = {金, 明姫 and 西尾, 忠 and 嶋田, 努 and 竹田, 和喜 and 横川, 弘一 and 宮本, 謙一},
 issue = {2},
 journal = {医療薬学 = Japanese Journal of Pharmaceutical Health Care and Sciences},
 month = {Apr},
 note = {A fully automated high-performance liquid chromatography system with column-switching was evaluated to determine the concentration of zonisamide (ZNS) in human plasma. After the plasma sample was diluted to 10-times with the mobile phase, the sample (101μL) was injected into the column-switching system without pretreatment. ZNS was detected by ultraviolet absorption at 246 nm. The calibration curve of ZNS was linear and ranged from 1.57 to 50μg/mL of plasma. The coefficients of variation in the within-run (n=5) and the between-run (5 days) precisions of ZNS were below 5 %. The limit of quantification was 0.5pg/mL in 1 μL of human plasma. A good correlation was found between the data obtained by this system and the ELISA system using Markit-M Excegran (r=0.956) or the solid-phase-extraction HPLC method (r=0.985). This system for ZNS is thus considered to be a very useful measurement for therapeutic drug monitoring because of its high sensitivity, rapidity and low cost compared with other measurement systems.},
 pages = {178--183},
 title = {カラムスイッチングHPLCシステムによるゾニサミドの高感度測定法の評価},
 volume = {29},
 year = {2003}
}