@article{oai:kanazawa-u.repo.nii.ac.jp:00026766,
 author = {Kayano, Daiki and Taki, Junichi and Fukuoka, Makoto and Wakabayashi, Hiroshi and Inaki, Anri and Nakamura, Ayane and Kinuya, Seigo},
 issue = {10},
 journal = {Nuclear Medicine Communications},
 month = {Oct},
 note = {OBJECTIVE: We assessed the lesion detectability of low-dose diagnostic 123I-metaiodobenzylguanidine (MIBG) whole-body scans obtained at 6 and 24 h compared with posttreatment 131I-MIBG whole-body scans in malignant pheochromocytoma and paraganglioma. METHODS: Scintigrams obtained in 15 patients with malignant pheochromocytoma and paraganglioma were retrospectively analyzed. Diagnostic scans were performed with 111 MBq of 123I-MIBG. Therapeutic doses of 131I-MIBG (5.55-7.40 GBq) were administrated and whole-body scans were obtained at 2-5 days after 123I-MIBG administrations. We compared the number of lesions and the lesion-to-referent count ratios at 6 and 24 h of 123I-MIBG and at 2-5 days of 131I-MIBG. RESULTS: In comparison with the 6-h images of 123I-MIBG, the 24-h images of 123I-MIBG could detect more lesions in eight patients. Posttreatment 131I-MIBG scans revealed new lesions in eight patients compared with the 24-h images of 123I- MIBG. The lesion-to-referent count ratios at 6 and 24 h of 131I-MIBG and at 3 days of 131I-MIBG were increasing at later scanning time. There were significant differences in the lesion-to-referent count ratios between 6 and 24 h of 123I-MIBG (P=0.031), 6 h of 131I-MIBG and 3 days of 123I-MIBG (P=0.020), and 24 h of 123I-MIBG and 3 days of 131I-MIBG (P=0.018). CONCLUSION: Low-dose diagnostic 123I-MIBG whole-body scan is inferior to posttreatment 131I-MIBG whole-body scan in malignant pheochromocytoma and paraganglioma. Considering the scan timing of 123I-MIBG, 6-h images might have no superiority compared with 24-h images. © 2011 Wolters Kluwer Health | Lippincott Williams &Wilkins.},
 pages = {941--946},
 title = {Low-dose 123I-metaiodobenzylguanidine diagnostic scan is inferior to 131I-metaiodobenzylguanidine posttreatment scan in detection of malignant pheochromocytoma and paraganglioma},
 volume = {32},
 year = {2011}
}