@article{oai:kanazawa-u.repo.nii.ac.jp:00026803,
 author = {志賀, 英明 and 瀧, 淳一 and 鷲山, 幸信 and 絹谷, 清剛 and 渡邉, 直人 and 利波, 久雄 and 越田, 吉郎 and 天野, 良平 and 古川, 仞 and 三輪, 高喜 and Shiga, Hideaki and Taki, Junichi and Washiyama, Kohshin and Yamamoto, Junpei and Kinase, Sakae and Okuda, Koichi and Kinuya, Seigo and Watanabe, Naoto and Tonami, Hisao and Koshida, Kichiro and Amano, Ryohei and Furukawa, Mitsuru and Miwa, Takaki},
 issue = {2},
 journal = {PLoS ONE},
 month = {Feb},
 note = {Purpose: The aim of this study was to assess whether migration of thallium-201 (201Tl) to the olfactory bulb were reduced in patients with olfactory impairments in comparison to healthy volunteers after nasal administration of 201Tl. Procedures: 10 healthy volunteers and 21 patients enrolled in the study (19 males and 12 females; 26-71 years old). The causes of olfactory dysfunction in the patients were head trauma (n = 7), upper respiratory tract infection (n = 7), and chronic rhinosinusitis (n = 7). 201TlCl was administered unilaterally to the olfactory cleft, and SPECT-CT was conducted 24 h later. Separate MRI images were merged with the SPECT images. 201Tl olfactory migration was also correlated with the volume of the olfactory bulb determined from MRI images, as well as with odor recognition thresholds measured by using T&T olfactometry. Results: Nasal201Tl migration to the olfactory bulb was significantly lower in the olfactory-impaired patients than in healthy volunteers. The migration of 201Tl to the olfactory bulb was significantly correlated with odor recognition thresholds obtained with T&T olfactometry and correlated with the volume of the olfactory bulb determined from MRI images when all subjects were included. Conclusions: Assessment of the 201Tl migration to the olfactory bulb was the new method for the evaluation of the olfactory nerve connectivity in patients with impaired olfaction. © 2013 Shiga et al.},
 title = {Assessment of Olfactory Nerve by SPECT-MRI Image with Nasal Thallium-201 Administration in Patients with Olfactory Impairments in Comparison to Healthy Volunteers},
 volume = {8},
 year = {2013}
}