{"created":"2023-07-27T06:38:39.674926+00:00","id":26804,"links":{},"metadata":{"_buckets":{"deposit":"11fe22b9-adb3-4fc9-84db-bf7c9dec5259"},"_deposit":{"created_by":3,"id":"26804","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"26804"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00026804","sets":["2268:2269:2270"]},"author_link":["30738","1880","22400","87","45293","115","88910","45295","22187","45291","45294","45292","43"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-03-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"436","bibliographicPageStart":"431","bibliographicVolumeNumber":"54","bibliographic_titles":[{"bibliographic_title":"Journal of Nuclear Medicine"}]}]},"item_4_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"瀧, 淳一"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"若林, 大志"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"稲木, 杏吏"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"小川, 数馬"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"柴, 和弘"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"絹谷, 清剛"}],"nameIdentifiers":[{},{},{},{}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"A relationship between L-[methyl-11C]methionine (11C-methionine) uptake and angiogenesis has been suggested in gliomas. However, methionine uptake in myocardial ischemia and reperfusion has received little attention. We investigated the serial changes and mechanisms of 14-Cmethionine uptake in a rat model of myocardial ischemia and reperfusion. Methods: The left coronary artery was occluded for 30 min, followed by reperfusion for 1-28 d. At the time of the study, 14-Cmethionine (0.74 MBq) and 201Tl (14.8 MBq) were injected intravenously at 20 and 10 min before sacrifice, respectively. One minute before sacrifice, the left coronary artery was reoccluded, and 99mTc-hexakis-2-methoxyisobutylisonitrile (150-180 MBq) was injected to verify the area at risk. Histologic sections of the heart were immunohistochemically analyzed using anti-CD68, anti-smooth-muscle a-actin (SMA), and antitroponin I and compared with the autoradiography findings. Results: Both 14Cmethionine (uptake ratio, 0.71 ± 0.13) and 201Tl uptake were reduced in the area at risk at 1 d after reperfusion. However, 3 d after reperfusion, an increased 14-Cmethionine uptake (1.79 ± 0.23) was observed corresponding to the area of still-reduced 201Tl uptake, and the 14-Cmethionine uptake gradually declined until 28 d. The increased 14-Cmethionine uptake area at 3 and 7 d corresponded well to the macrophage infiltrations demonstrated by positive CD68 staining. Anti-SMA staining appeared at 7 d, after which CD68 staining was gradually replaced by the SMA staining, suggesting that methionine uptake in the early phase after ischemia and reperfusion might reflect inflammatory activity. Conclusion: 14-Cmethionine accumulated in the infarcted area, and its uptake corresponded closely to macrophage infiltration at 3-7 d after reperfusion. Methionine imaging may be useful for inflammatory imaging early after myocardial infarction. COPYRIGHT © 2013 by the Society of Nuclear Medicine and Molecular Imaging, Inc.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学新学術創成研究機構 / 金沢大学附属病院","subitem_description_type":"Other"}]},"item_4_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00026791","subitem_identifier_reg_type":"JaLC"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Society of Nuclear Medicine"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.2967/jnumed.112.112060","subitem_relation_type_select":"DOI"}}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA00703684","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0161-5505","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Taki, Junichi"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Wakabayashi, Hiroshi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Inaki, Anri"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Imanaka-Yoshida, Kyoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hiroe, Michiaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ogawa, Kazuma"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Morooka, Miyako"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kubota, Kazuo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shiba, Kazuhiro"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Yoshida, Toshimichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kinuya, Seigo"}],"nameIdentifiers":[{},{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"HO-PR-TAKI-J-431.pdf","filesize":[{"value":"866.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-TAKI-J-431.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/26804/files/HO-PR-TAKI-J-431.pdf"},"version_id":"89fddb9f-c266-4e52-81c3-baa1e2ca1aef"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"14-Cmethionine uptake as a potential marker of inflammatory processes after myocardial ischemia and reperfusion","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"14-Cmethionine uptake as a potential marker of inflammatory processes after myocardial ischemia and reperfusion"}]},"item_type_id":"4","owner":"3","path":["2270"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"26804","relation_version_is_last":true,"title":["14-Cmethionine uptake as a potential marker of inflammatory processes after myocardial ischemia and reperfusion"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T10:13:36.312690+00:00"}