@article{oai:kanazawa-u.repo.nii.ac.jp:00026820, author = {Ohtsubo, Koushiro and Watanabe, Hiroyuki and Yamada, Tadaaki and Tsuchiyama, Tomoya and Mouri, Hisatsugu and Yamashita, Kaname and Yasumoto, Kazuo and Ikeda, Hiroko and Nakanuma, Yasuni and Yano, Seiji}, issue = {18}, journal = {Internal Medicine}, month = {Jan}, note = {We report a 47-year-old man with cancer of unknown primary site in whom pancreatic cancer was confirmed at autopsy. Although a primary lesion was not confirmed, we planned to perform tumor marker-oriented chemotherapy because pancreatic cancer was suspected as the primary lesion based on tumor markers and pathological findings from metastatic lymph node. Neither S-1 nor gemcitabine was effective. However, gemcitabine combined with low-dose cisplatin therapy resulted in a marked decrease in the size of tumors. Microscopic examination at autopsy revealed poorly differentiated adenocarcinoma in the pancreatic head, although a pancreatic mass was not clear macroscopically. © 2009 The Japanese Society of Internal Medicine., 金沢大学医学部附属病院がん高度先進治療センター}, pages = {1651--1656}, title = {Cancer of unknown primary site in which tumor marker-oriented chemotherapy was effective and pancreatic cancer was finally confirmed at autopsy}, volume = {48}, year = {2009} }