{"created":"2023-07-27T06:38:43.555777+00:00","id":26892,"links":{},"metadata":{"_buckets":{"deposit":"4defc627-7057-403d-bf67-e97dfc7ed0a0"},"_deposit":{"created_by":3,"id":"26892","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"26892"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00026892","sets":["1761:1762:1763"]},"author_link":["21707","21711","21709"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1999-09-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"763","bibliographicPageStart":"757","bibliographicVolumeNumber":"20","bibliographic_titles":[{"bibliographic_title":"胆と膵 = The Biliary tract & pancreas"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"膵癌では胃癌や大腸癌のように生検が行えないことが, その早期診断や鑑別診断を困難にしているが, K－rasコドン12の変異が高率にみられることに注目し, 膵液中K－ras変異の検出が試みられている. しかし, その陽性率は高いものの, 偽陽性がかなりみられ, 癌特異性が問題になっている. このような点を補完し, 膵液中DNA診断の向上を目指して, 私共は, p53癌抑制遺伝子変異の有無をnon－RI－SSCP法にて検討している. 本法によるp53遺伝子変異（エクソン5～8）は膵癌の42.3%（11/26）に認められている. 一方, 粘液産生膵腫瘍（腺腫）4例と慢性膵炎16例の膵液には同変異は検出されず, その癌特異性は非常に高い. また, K－ras変異陰性例にもp53変異陽性例がみられ, K－ras変異と組み合わせることにより, 膵癌の遺伝子診断が向上する.","subitem_description_type":"Abstract"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"医学図書出版"}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.igakutosho.co.jp/","subitem_relation_type_select":"URI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © 医学図書出版 | 許可を得て登録"}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00333226","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0388-9408","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"渡邊, 弘之"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"山口, 泰志"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"澤武, 紀雄"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"CA-PR-WATANABE-H-757.pdf","filesize":[{"value":"4.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"CA-PR-WATANABE-H-757.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/26892/files/CA-PR-WATANABE-H-757.pdf"},"version_id":"50576886-7d61-428d-ad82-6ca8b498932d"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"p53癌抑制遺伝子変異検索の膵癌診断","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"p53癌抑制遺伝子変異検索の膵癌診断"},{"subitem_title":"Detection of P53 Suppressor Gene Mutations in the Diagnosis of Pancreatic Cancer","subitem_title_language":"en"}]},"item_type_id":"4","owner":"3","path":["1763"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"26892","relation_version_is_last":true,"title":["p53癌抑制遺伝子変異検索の膵癌診断"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-27T21:17:02.319883+00:00"}