{"created":"2023-07-27T06:38:43.988533+00:00","id":26902,"links":{},"metadata":{"_buckets":{"deposit":"d0fb2f60-59a4-457a-875b-0f81c85c26a3"},"_deposit":{"created_by":3,"id":"26902","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"26902"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00026902","sets":["1761:1762:1763"]},"author_link":["45462","22059","22233","458","695","1526"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-01-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"183","bibliographicPageStart":"178","bibliographicVolumeNumber":"29","bibliographic_titles":[{"bibliographic_title":"医療薬学 = Japanese journal of pharmaceutical health care and sciences"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"A fully automated high-performance liquid chromatography system with column-switching was evaluated to determine the concentration of zonisamide (ZNS) in human plasma. After the plasma sample was diluted to 10-times with the mobile phase, the sample (101μL) was injected into the column-switching system without pretreatment. ZNS was detected by ultraviolet absorption at 246 nm. The calibration curve of ZNS was linear and ranged from 1.57 to 50μg/mL of plasma. The coefficients of variation in the within-run (n=5) and the between-run (5 days) precisions of ZNS were below 5 %. The limit of quantification was 0.5pg/mL in 1 μL of human plasma. A good correlation was found between the data obtained by this system and the ELISA system using Markit-M Excegran (r=0.956) or the solid-phase-extraction HPLC method (r=0.985). This system for ZNS is thus considered to be a very useful measurement for therapeutic drug monitoring because of its high sensitivity, rapidity and low cost compared with other measurement systems.","subitem_description_type":"Abstract"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本医療薬学会 = Japanese Society of Pharmaceutical Health Care and Sciences"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.5649/jjphcs.29.178","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.jsphcs.jp/","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.jstage.jst.go.jp/browse/jjphcs/-char/ja","subitem_relation_type_select":"URI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © JSPHCS. 日本医療薬学会 Japanese Society of Pharmaceutical Health Care and Sciences"}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA11527197","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1346-342X","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"金, 明姫"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"西尾, 忠"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"嶋田, 努"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"竹田, 和喜"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"横川, 弘一"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"宮本, 謙一"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"PH-PR-SHIMADA-T-178.pdf","filesize":[{"value":"720.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PH-PR-SHIMADA-T-178.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/26902/files/PH-PR-SHIMADA-T-178.pdf"},"version_id":"9d8ae1ba-fc81-4ed5-921b-27f27818221a"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"カラムスイッチングHPLCシステムによるゾニサミドの高感度測定法の評価","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"カラムスイッチングHPLCシステムによるゾニサミドの高感度測定法の評価"},{"subitem_title":"Evaluation of a Highly Sensitive Measurement Method of Zonisamide by an HPLCSystem with Column-Switching","subitem_title_language":"en"}]},"item_type_id":"4","owner":"3","path":["1763"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"26902","relation_version_is_last":true,"title":["カラムスイッチングHPLCシステムによるゾニサミドの高感度測定法の評価"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-27T21:16:51.107415+00:00"}