@article{oai:kanazawa-u.repo.nii.ac.jp:00026979,
 author = {Saito, Yuta and Hasebe-Takenaka, Yasuko and Ueda, Toshihiko and Nakanishi-Ueda, Takako and Kosuge, Shotaro and Aburada, Masaki and Shimada, Tsutomu and Ikeya, Yukinobu and Onda, Hidetoshi and Ogura, Hirotsugu and Taguchi, Yoko and Yasuhara, Hajime and Koide, Ryohei},
 issue = {1},
 journal = {Journal of Clinical Biochemistry and Nutrition},
 month = {Jul},
 note = {This study aimed to investigate the preventive effects of green tea fractions (GTFs) on rat model of oxygen-induced retinopathy (OIR). Neonatal Sprague-Dawley rats were exposed to daily cycles of 80% oxygen (20.5 h), ambient air (0.5 h), and progressive return to 80% oxygen (3 h) until postnatal day 12 (P12), then the rats were placed in ambient air until P18. The green tea was fractionated by DM-A50, DM-W, M-B, and M-W. The rats were treated once daily from P6 to P17 by gastric gavage of GTFs (0.05 or 0.01 g/ml) or distilled water (DW) at 50 μl/10 g body weight. On P18, the rats were sacrificed and the retinal samples were collected. The retinal neovascularization (NV) was scored and avascular areas (AVAs) were measured as a % of total retinal area (%AVAs) in ADPase stained retinas. The NV scores in 0.01 g/ml M-W were significantly lower than those in DW. The %AVAs in 0.05 g/ml DM-A50 and in 0.05 g/ml and 0.01 g/ml M-W were significantly lower than those in DW. There were less catechins, and less caffeine in M-W fraction compared with other GTFs, suggesting components of green tea except for catechins and caffeine might suppress the neovascularization in rat model of OIR.},
 pages = {43--49},
 title = {Effects of green tea fractions on oxygen-induced retinal neovascularization in the neonatal rat},
 volume = {41},
 year = {2007}
}