{"created":"2023-07-27T06:38:47.813249+00:00","id":26992,"links":{},"metadata":{"_buckets":{"deposit":"8cae2a6d-09c8-4c3f-a8fa-5ae86f54b3a8"},"_deposit":{"created_by":3,"id":"26992","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"26992"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00026992","sets":["1761:1762:1763"]},"author_link":["44934","62445","22059","48990","45301","48987","975","45732","282","1433","458","111959","88085","45262","111958","45731","30802"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-10-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageEnd":"1639","bibliographicPageStart":"1635","bibliographicVolumeNumber":"32","bibliographic_titles":[{"bibliographic_title":"癌と化学療法"}]}]},"item_4_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yonemura, Yutaka"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Endo, Yoshio"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Tochiori, Shizuka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Bando, Etsurou"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawamura, Taiichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shimada, Tsutomu"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Miyamoto, Ken-ichi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Tanaka, Motohiro"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Sasaki, Takuma"}],"nameIdentifiers":[{},{}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In vitro chemosensitivity test using a collagen-gel method was done on 165 primary gastric cancers. All of 5-FU, CBDCA, CDDP and docetaxel showed a high sensitivity. The effects of per oral (po) administration of TS-1, a combination of po TS-1 and intraperitoneal (ip) administration of CDDP, ip 5-FU and ip docetaxel, were evaluated in athymic mice bearing peritoneal dissemination of a gastric cancer cell line (MKN-45-P that shows a high rate of metastasis to the peritoneal cavity of nude mice). Nude mice were inoculated by ip with 10(7) MKN-45-P cells. No survival benefit was obtained after po administration of TS-1 (12 mg/kg) alone or ip CDDP alone. However, a combination of po TS-1 (8 mg/kg x 10 days, from day 3) and ip CDDP (3.5 mg/kg, day 6 and 13) showed a significant survival improvement than that of po TS-1 or ip CDDP treatment alone. ip administration of 30 mg/kg (3 times/week x 3 weeks) or 15 mg/kg (6 times/week x 3 weeks) of 5-FU significantly improved the survival of mice bearing MKN-45-P. 5-FU concentration of ascites after ip administration of 30 mg/kg of 5-FU was 600-fold higher than po administration of 12 mg/kg of TS-1 at peak level. ip injections of docetaxel of 8 mg/kg, and 2 mg/kg improved the survival of 4 and 1 mice, respectively, and they were tumor-free on day 90. Survival of mice treated with ip injection of CBDCA (100 mg/kg, on day 3, or 50 mg/ kg on day 3 and 10) was significantly better than the control group. These results suggest the potential of po TS-1 + ip CDDP, ip 5-FU, ip docetaxel and ip CBDCA administration for the treatment of peritoneal dissemination of gastric cancer.コラーゲンゲル法により原発胃癌の薬剤感受性を調べたところ, CBDCA, CDDP, 5-FU, docetaxel(DOC)が高い感受性を示した. 胃癌高度腹膜転移株MKN-45-PをTS-1(12mg/kg)で治療した群では, 治療開始日に関係なく対照群の生存率と差がなかった. 5-FU 15mg/kg ip, 18回, 30mg/kg ip, 9回投与群ではTS-1 12mg/kg po(計20回)や対照群に比べ有意に生存率がよかった. 5-FU 30mg/kg ip投与群の注入液の5-FU濃度は600μg/mlと高値を示した. TS-1 12mg/kg投与60分での腹水中5-FU, CDHP濃度は927±558ng/ml, 1,483±719ng/mlであった. CDDP3.5mg ip投与(6, 13日)群, TS-1単独群, 対照群ではMST36, 28, 32日で差を認めなかった. しかし, CDDP+TS-1(8mg/kg)群ではMST50日で有意に他の3群より生存率が良好であった. DOC8mg/kg, 2mg/kg ip投与群ではMST90, 63日で, それぞれ4匹, 1匹は腹膜播種が消失していた. DOC8mg/kg ip投与後は8時間後も腹水中DOC濃度(4.58±0.28μg/ml)は高い濃度を維持していたが, iv投与では腹水中濃度はip投与後に比べ1/100の値であった. また, 腹膜播種組織内のDoc濃度はip投与8時間ではiv投与後に比べ有意に高い値(4.65±1.33μg/gr)を示した. CBDCA50mg/kg(day3, 7ip)100mg/kg(day3, ip)投与群では有意に対照群より生存率が良好であった. MSTは対照群26.3日, 100mg/kg群37.7日, 50mg/kg群40.3日であった. しかし, 体重減少を認めた例はなかった. 以上より胃癌高度腹膜転移株MKN-45-Pによる腹膜播種モデルにおいて, 5-Fu ip, Ts-1 po+CDDP ip, Doc ip, CBDCA ip療法は有効であり, 臨床への応用が期待される.","subitem_description_type":"Abstract"}]},"item_4_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00026979","subitem_identifier_reg_type":"JaLC"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"癌と化学療法社"}]},"item_4_relation_13":{"attribute_name":"PMID","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"16315893","subitem_relation_type_select":"PMID"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://ccpgan.com/","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://ccpgan.com/page/19","subitem_relation_type_select":"URI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © 2005 癌と化学療法社"}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA12405504","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0385-0684","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"米村, 豊"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"遠藤, 良夫"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"栃折, 静"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"坂東, 悦郎"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"川村, 泰一"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"嶋田, 努"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"宮本, 謙一"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"田中, 基弘"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"佐々木, 琢磨"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"PH-PR-SHIMADA-T-1635.pdf","filesize":[{"value":"3.5 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-SHIMADA-T-1635.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/26992/files/PH-PR-SHIMADA-T-1635.pdf"},"version_id":"967e5167-77fa-449f-822d-9d0b7ef36df3"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"実験的胃癌腹膜播種に対する腹腔内化学療法の効果","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"実験的胃癌腹膜播種に対する腹腔内化学療法の効果"},{"subitem_title":"Effect of intraperitoneal chemotherapy on experimental peritoneal dissemination of gastric cancer","subitem_title_language":"en"}]},"item_type_id":"4","owner":"3","path":["1763"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"26992","relation_version_is_last":true,"title":["実験的胃癌腹膜播種に対する腹腔内化学療法の効果"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T09:16:14.719540+00:00"}