@article{oai:kanazawa-u.repo.nii.ac.jp:00027015,
 author = {Yoshizawa, Kunio and Nozaki, Shinichi and Okamune, Ayako and Kitahara, Hiroko and Ohara, Teruhisa and Kato, Koroku and Kawashiri, Shuichi and Yamamoto, Etsuhide},
 issue = {6},
 journal = {Journal of Oral Pathology and Medicine},
 month = {Jul},
 note = {Objective: Maspin, a 42-kDa protein, belongs to the serpin family of protease inhibitors and is known to have tumor-suppressor function. In this study, we investigated the interrelationship between clinicopathologic findings and maspin expression in oral squamous cell carcinoma (OSCC). Methods: Using immunohistochemical techniques to examine the expression levels of maspin in OSCC, maspin expression in OSCC was detected in 46 (64.8%) of 71 cases. We also compared the clonicopathologic features of OSCC cases with maspin expression levels. Moreover, we examined expression of maspin in eight cell lines derived from OSCC using reverse transcriptase-polymerase chain reaction (RT-PCR) and Western blotting. Results: There was a significant correlation between decreased maspin expression and T-category (P < 0.01), lymph metastasis (P < 0.0001), and mode of invasion (P < 0.0001). Patients with positive maspin expression had a significantly better prognosis (P < 0.001). Lower expression of maspin was also seen in cell lines derived from grade 4D, which shows stronger invasive potential than other grades of OSCC. Conclusion: Maspin may be a useful marker to identify the potential for progression in OSCC. © 2008 Blackwell Munksgaard., 金沢大学附属病院歯科口腔外科},
 pages = {535--539},
 title = {Loss of maspin is a negative prognostic factor for invasion and metastasis in oral squamous cell carcinoma},
 volume = {38},
 year = {2009}
}