{"created":"2023-07-27T06:38:48.810997+00:00","id":27015,"links":{},"metadata":{"_buckets":{"deposit":"e5cd6eab-8913-4e0d-a05c-ff09eb6c2e77"},"_deposit":{"created_by":3,"id":"27015","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"27015"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00027015","sets":["1761:1762:1763"]},"author_link":["31330","45811","110","157","445","45808","45809","45810"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-07-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"539","bibliographicPageStart":"535","bibliographicVolumeNumber":"38","bibliographic_titles":[{"bibliographic_title":"Journal of Oral Pathology and Medicine"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objective: Maspin, a 42-kDa protein, belongs to the serpin family of protease inhibitors and is known to have tumor-suppressor function. In this study, we investigated the interrelationship between clinicopathologic findings and maspin expression in oral squamous cell carcinoma (OSCC). Methods: Using immunohistochemical techniques to examine the expression levels of maspin in OSCC, maspin expression in OSCC was detected in 46 (64.8%) of 71 cases. We also compared the clonicopathologic features of OSCC cases with maspin expression levels. Moreover, we examined expression of maspin in eight cell lines derived from OSCC using reverse transcriptase-polymerase chain reaction (RT-PCR) and Western blotting. Results: There was a significant correlation between decreased maspin expression and T-category (P < 0.01), lymph metastasis (P < 0.0001), and mode of invasion (P < 0.0001). Patients with positive maspin expression had a significantly better prognosis (P < 0.001). Lower expression of maspin was also seen in cell lines derived from grade 4D, which shows stronger invasive potential than other grades of OSCC. Conclusion: Maspin may be a useful marker to identify the potential for progression in OSCC. © 2008 Blackwell Munksgaard.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院歯科口腔外科","subitem_description_type":"Other"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"John Wiley & Sons"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1111/j.1600-0714.2009.00762.x","subitem_relation_type_select":"DOI"}}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA10715555","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0904-2512","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yoshizawa, Kunio"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Nozaki, Shinichi"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Okamune, Ayako"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kitahara, Hiroko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ohara, Teruhisa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kato, Koroku"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Kawashiri, Shuichi"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Yamamoto, Etsuhide"}],"nameIdentifiers":[{},{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"HO-PR-YOSHIZAWA-K-535.pdf","filesize":[{"value":"299.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HO-PR-YOSHIZAWA-K-535.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/27015/files/HO-PR-YOSHIZAWA-K-535.pdf"},"version_id":"a5b5a7cd-c29e-4e68-8999-00c0a7fa71e5"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Loss of maspin is a negative prognostic factor for invasion and metastasis in oral squamous cell carcinoma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Loss of maspin is a negative prognostic factor for invasion and metastasis in oral squamous cell carcinoma"}]},"item_type_id":"4","owner":"3","path":["1763"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"27015","relation_version_is_last":true,"title":["Loss of maspin is a negative prognostic factor for invasion and metastasis in oral squamous cell carcinoma"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-27T21:14:53.546058+00:00"}