@article{oai:kanazawa-u.repo.nii.ac.jp:00027016,
 author = {Nakamura, Mitsuhiro and Bodily, Jason M. and Beglina, Melanie and Kyo, Satoru and Inoue, Masaki and Laimins, Laimonis A.},
 issue = {2},
 journal = {Virology},
 month = {May},
 note = {Human papillomaviruses (HPV) are the causative agents of cervical cancer and have been shown to increase expression of pro-angiogenic factors from infected cells. Many angiogenic factors are regulated by hypoxia inducible factor 1α (HIF-1α). We investigated whether HPV31 affects the levels of HIF-1α under normal and hypoxic conditions. Our studies indicate that cells containing complete HPV31 genomes showed enhanced levels of HIF-1α upon treatment with the hypoxia mimic DFO, which resulted from protein stabilization and led to increased expression of some but not all HIF-1α target genes. Both HPV E6 and E7 were able independently to enhance induction of HIF-1α upon DFO treatment. Enhancement of HIF-1α stability was not restricted to high-risk HPV types, as HPV11, a low risk HPV type, mediated a similar effect. These findings shed light on mechanisms by which HPV contributes to angiogenesis both in benign cervical lesions and in cervical cancers. © 2009 Elsevier Inc. All rights reserved., 金沢大学附属病院産科婦人科},
 pages = {442--448},
 title = {Hypoxia-specific stabilization of HIF-1alpha by human papillomaviruses},
 volume = {387},
 year = {2009}
}