{"created":"2023-07-27T06:38:48.853736+00:00","id":27016,"links":{},"metadata":{"_buckets":{"deposit":"38ccb9f5-0696-4d6d-b362-1063a7fb9433"},"_deposit":{"created_by":3,"id":"27016","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"27016"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00027016","sets":["1761:1762:1763"]},"author_link":["45814","45813","24303","45812","37","20086"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-05-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"448","bibliographicPageStart":"442","bibliographicVolumeNumber":"387","bibliographic_titles":[{"bibliographic_title":"Virology"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Human papillomaviruses (HPV) are the causative agents of cervical cancer and have been shown to increase expression of pro-angiogenic factors from infected cells. Many angiogenic factors are regulated by hypoxia inducible factor 1α (HIF-1α). We investigated whether HPV31 affects the levels of HIF-1α under normal and hypoxic conditions. Our studies indicate that cells containing complete HPV31 genomes showed enhanced levels of HIF-1α upon treatment with the hypoxia mimic DFO, which resulted from protein stabilization and led to increased expression of some but not all HIF-1α target genes. Both HPV E6 and E7 were able independently to enhance induction of HIF-1α upon DFO treatment. Enhancement of HIF-1α stability was not restricted to high-risk HPV types, as HPV11, a low risk HPV type, mediated a similar effect. These findings shed light on mechanisms by which HPV contributes to angiogenesis both in benign cervical lesions and in cervical cancers. © 2009 Elsevier Inc. All rights reserved.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院産科婦人科","subitem_description_type":"Other"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.virol.2009.02.036","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.elsevier.com/locate/issn/00426822","subitem_relation_type_select":"URI"}}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA00884454","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0042-6822","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nakamura, Mitsuhiro"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Bodily, Jason M."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Beglina, Melanie"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kyo, Satoru"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Inoue, Masaki"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Laimins, Laimonis A."}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"HO-PR-NAKAMURA-M-442.pdf","filesize":[{"value":"213.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HO-PR-NAKAMURA-M-442.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/27016/files/HO-PR-NAKAMURA-M-442.pdf"},"version_id":"6de4e8b8-e7ac-45e9-843d-e9314281078c"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Hypoxia-specific stabilization of HIF-1alpha by human papillomaviruses","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Hypoxia-specific stabilization of HIF-1alpha by human papillomaviruses"}]},"item_type_id":"4","owner":"3","path":["1763"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"27016","relation_version_is_last":true,"title":["Hypoxia-specific stabilization of HIF-1alpha by human papillomaviruses"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-27T21:14:50.995802+00:00"}