{"created":"2023-07-27T06:38:49.672850+00:00","id":27035,"links":{},"metadata":{"_buckets":{"deposit":"b615b1fd-dd97-4656-aac6-4de6c9fe59a8"},"_deposit":{"created_by":3,"id":"27035","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"27035"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00027035","sets":["4281:4291:4312"]},"author_link":["45860","45861","22059","2702","86","45863","568","45862","45858","45859"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-01-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageEnd":"1871","bibliographicPageStart":"1867","bibliographicVolumeNumber":"33","bibliographic_titles":[{"bibliographic_title":"Biological and Pharmaceutical Bulletin"}]}]},"item_4_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"長田, 直人"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"崔, 吉道"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"宮本, 謙一"}],"nameIdentifiers":[{},{}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The present study examined the influence of cimetidine on the nephrotoxicity and antitumor effects of cisplatin in vitro and in vivo. When the serum concentration of cimetidine was maintained over 20 μg/ml for 4 h by bolus and continuous intravenous infusion, cimetidine prevented nephrotoxicity of cisplatin without influencing antitumor activity. Cimetidine and the antioxidant N-acetylcysteine (NAC) significantly inhibited the in vitro growth inhibition of cisplatin in cells originating from the kidney, but not in SOSN2 osteosarcoma cells. Cimetidine (1mM) also did not influence platinum concentration in the cells, regardless of whether the organic cation transporter 2 (OCT2) was expressed. Cisplatin did induce reactive oxygen species (ROS) in the KN41 kidney cell line and cimetidine and NAC significantly reduced ROS production. However, cisplatin did not produce ROS in osteosarcoma cells. From these results, cimetidine clearly inhibits nephrotoxicity induced by cisplatin without any influence on the antitumor activity of cisplatin on osteosarcoma in vitro and in vivo. © 2010 Pharmaceutical Society of Japan.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院薬剤部","subitem_description_type":"Other"}]},"item_4_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00027022","subitem_identifier_reg_type":"JaLC"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Pharmaceutical Society of Japan = 日本薬学会"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1248/bpb.33.1867","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.jstage.jst.go.jp/article/bpb/33/11/33_1867/_article","subitem_relation_type_select":"URI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"(c) 2010 The Pharmaceutical Society of Japan"}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA10885497","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0918-6158","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Katsuda, Hiromu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamashita, Mariko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Katsura, Hideyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yu, Jia"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Waki, Yoshihiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagata, Naoto"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Sai, Yoshimichi"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Miyamoto, Kenichi"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"PH-PR-MIYAMOTO-K-1867.pdf","filesize":[{"value":"262.1 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-MIYAMOTO-K-1867.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/27035/files/PH-PR-MIYAMOTO-K-1867.pdf"},"version_id":"657fa2d4-221e-43e9-ac73-cf1fa816c442"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Protecting cisplatin-induced nephrotoxicity with cimetidine does not affect antitumor activity","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Protecting cisplatin-induced nephrotoxicity with cimetidine does not affect antitumor activity"}]},"item_type_id":"4","owner":"3","path":["4312"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"27035","relation_version_is_last":true,"title":["Protecting cisplatin-induced nephrotoxicity with cimetidine does not affect antitumor activity"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T08:51:12.715020+00:00"}