{"created":"2023-07-27T06:38:50.701458+00:00","id":27060,"links":{},"metadata":{"_buckets":{"deposit":"77a20d75-26dd-4c03-9a87-678567f9dd6d"},"_deposit":{"created_by":3,"id":"27060","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"27060"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00027060","sets":["1761:1762:1763"]},"author_link":["45951","21542","45952","45949","45950","20094"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-10-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"348","bibliographicPageStart":"341","bibliographicVolumeNumber":"58","bibliographic_titles":[{"bibliographic_title":"Journal of Physiological Sciences"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The mechanisms of the protective effect conferred by heat shock preconditioning (HS) are currently unknown. The purpose of this study was to determine the effect of HS on muscle injury after downhill running and to address the mechanism of the effect. Female Wistar rats were assigned to three groups: HS, downhill running (E), and downhill running after heat shock preconditioning (HS + E). The HS and HS + E rats were placed in a heat chamber for 60 min (ambient temperature 42 ± 1.0°C) 48 h before downhill running. Reactive oxygen species (ROS) scavenging activity was determined by electron spin resonance (ESR), and heat shock protein 72 (HSP72) mRNA expression was measured in rat quadriceps femoris. Leukocyte infiltration and degenerated muscle fibers were determined histopathologically. ROS scavenging activity significantly increased at 3 days after HS (151 ± 18%) and HSP72 mRNA expression increased immediately after HS (1750 ± 1914%). No decrease in ROS scavenging activity was observed in the HS + E rats at 2 days after exercise compared with the E rats (102 ± 9% vs. 79 ± 5%). Degenerated muscle fibers in HS + E rats were significantly less than in E rats at 2, 3, and 7 days after exercise (0.8 ± 1.0 vs. 2.8 ± 1.6, 0.8 ± 1.0 vs. 1.8 ± 1.6, 0 vs. 0.3 ± 0.6, respectively). These data demonstrated that HS can reduce muscle injury after downhill running, and this effect may be mediated by increased ROS scavenging activity. Furthermore, HS may protect the antioxidant defense system in skeletal muscle by enhancing the adaptive HSP72 mRNA response.全文公開200910","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院整形外科","subitem_description_type":"Other"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本生理学会"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.2170/physiolsci.RP004808","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.2170/physiolsci.RP004808","subitem_relation_type_select":"DOI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.jstage.jst.go.jp/article/physiolsci/58/5/58_341/_article","subitem_relation_type_select":"URI"}}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA12129145","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1880-6546","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shima, Yosuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kitaoka, Katsuhiko"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Yoshiki, Yumiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Maruhashi, Yoshinobu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsuyama, Takeshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tomita, Katsuro"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"HO-PR-SHIMA-Y-341.pdf","filesize":[{"value":"332.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HO-PR-SHIMA-Y-341.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/27060/files/HO-PR-SHIMA-Y-341.pdf"},"version_id":"f85c8246-9c59-4156-a75e-8b2a1ae3abca"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effect of heat shock preconditioning on ROS scavenging activity in rat skeletal muscle after downhill running","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effect of heat shock preconditioning on ROS scavenging activity in rat skeletal muscle after downhill running"}]},"item_type_id":"4","owner":"3","path":["1763"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"27060","relation_version_is_last":true,"title":["Effect of heat shock preconditioning on ROS scavenging activity in rat skeletal muscle after downhill running"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-27T21:13:58.497313+00:00"}