@article{oai:kanazawa-u.repo.nii.ac.jp:00027088, author = {Kitagawa, Hirohisa and Ohta, Tetsuo and Makino, Isamu and Tani, Takashi and Tajima, Hidehiro and Nakagawara, Hisatoshi and Ohnishi, Ichiro and Takamura, Hiroyuki and Kayahara, Masato and Watanabe, Hiroyuki and Gabata, Toshifumi and Matsui, Osamu and Zen, Yoh}, issue = {7}, journal = {Frontiers in Bioscience}, month = {Jan}, note = {In patients with carcinoma of the head of the pancreas with positive lymph nodes, the extent of an adequate lymph node dissection beyond peripancreatic area has remained controversial. Based on the two anlagens, the ventral or dorsal pancreas, we assessed the lymphatic spread pattern in 58 primary adenocarcinoma of head of the pancreas. Detection of lymph node mestastasis was based on microscopic detection of carcinoma in consecutive serial sections of resected specimens including lymph nodes. When the tumor was confined to the ventral pancreas domain (n=20), the lymph node metastases were limited to areas along the superior mesenteric artery (SMA) besides peripancreatic lymph nodes. When the tumor was in the dorsal pancreas domain (n=6), the lymph node metastases were limited to areas along the common hepatic artery (CHA) and the hepatoduodenal ligament besides peripancreatic lymph nodes. When the tumor was extended into both domains (n=32), the lymph node metastases were distributed widely in areas along the SMA, CHA and the hepatoduodenal ligament besides peripancreatic lymph nodes. Based on these findings, the lymphatic spread of carcinomas of the head of the pancreas can be divided into two patterns by tumor location based on the two anlagens of the pancreas., 金沢大学医学部附属病院肝胆膵・移植外科}, pages = {2728--2735}, title = {Carcinomas of the ventral and dorsal pancreas exhibit different patterns of lymphatic spread}, volume = {13}, year = {2008} }