{"created":"2023-07-27T06:38:52.553772+00:00","id":27103,"links":{},"metadata":{"_buckets":{"deposit":"b4777311-591a-4931-8467-2b834882fa0e"},"_deposit":{"created_by":3,"id":"27103","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"27103"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00027103","sets":["1761:1762:1763"]},"author_link":["22396","46109","46108"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1993-10-18","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageEnd":"728","bibliographicPageStart":"721","bibliographicVolumeNumber":"30","bibliographic_titles":[{"bibliographic_title":"The Japanese Journal of Rehabilitation Medicine = リハビリテーション医学"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"脊髄損傷におけるPDWHFの効果を血管新生の立場から検討した.猫の腰髄に22Gテフロン針を刺入し脊髄不全損傷を作製した.PDWHF処置群はテフロン針にPDWHFがコ-ティングされ,非処置群にはコ-ティングされない二重盲検法を採用した.臨床的には後肢運動機能,電気生理学的には各種誘発電位を測定し,3週間で脊髄を摘出し組織学的に評価した.電気生理ならびに臨床的にはPDWHF処置群,非処置群ともテフロン針刺入により脊髄不全麻癖を呈し,3週間の経過観察ではPDWHF処置群でより回復が良好と思われたが.統計学的に有意差を認めなかった.組織学的にはPDWHF処置群で著しい血管新生と血管拡張所見が損傷部周囲にみられた.今回の限局した脊髄損傷とPDWHF供給により血管新生が誘導されることが判明し,これにより血流増加が損傷部位およびその周囲に起こると考えられた. The main purpose of this study was to investigate the usefulness of platelet derived wound healing formula (PDWHF) in experimentally induced spinal cord injuries in cats. The injury model in 10 adult cats consisted of the placement of three 22 gauge teflon catheter sheaths into the spinal cord at the L2 level. Administration of PDWHF was achieved by coating theses sheaths with PDWHF In Hydron. Three animals were used as controls. In the 7 remaining cats, administration of PDWHF was double blinded. Cats were sacrificed at 3 weeks after injury and injured spinal cord segments were excised for histologic evaluation. Electrophysiologic and clinical motor function were evaluated throughout the period of observation. Evoked potentials in both groups indicated incomplete spinal cord lesions due to insertion of the needles. There appeared to be improvement of the evoked response and clinical function as a result of administration of PDWHF at 3 weeks after injury, though there was no significance. The histologic findings in the PDWHF group showed significant new vessel formation as well as dilation around the injured site. This neovascularization, both qualitative and quantitative, was noted in the PDWHF group. This information with a limited injury and simple delivery system for growth factor would suggest that there is neovascularization occurring as a result of I)DWHF administration.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院リハビリテーション部","subitem_description_type":"Other"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"The Japanese Association of Rehabilitation Medicine = 日本リハビリテーション医学会"}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.jarm.or.jp/","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://ci.nii.ac.jp/naid/110001861198/en/","subitem_relation_type_select":"URI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"本文データは日本リハビリテーション医学会の許諾に基づきCiNiiから複製したものである"}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00250275","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0034-351X","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"平泉, 裕"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"長田, 茂樹"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"川原, 範夫"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"HO-PR-KAWAHARA-N-721.pdf","filesize":[{"value":"785.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HO-PR-KAWAHARA-N-721.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/27103/files/HO-PR-KAWAHARA-N-721.pdf"},"version_id":"ebe21793-54f6-4edd-b07c-3ad8f562efec"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"損傷脊髄修復のための基礎的実験 : 血小板由来創傷治癒因子(PDWHF)による生体内血管新生","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"損傷脊髄修復のための基礎的実験 : 血小板由来創傷治癒因子(PDWHF)による生体内血管新生"},{"subitem_title":"Experimental Study for Recovery of Injured Spinal Cord : In Vivo Angiogenesis by Platelet Derived Wound Healing Formula (PDWHF)","subitem_title_language":"en"}]},"item_type_id":"4","owner":"3","path":["1763"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"27103","relation_version_is_last":true,"title":["損傷脊髄修復のための基礎的実験 : 血小板由来創傷治癒因子(PDWHF)による生体内血管新生"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-27T21:13:05.943552+00:00"}