| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-10-05 |
| タイトル |
|
|
タイトル |
Tetraspanin CD63 Promotes Targetion and Lysosomal Proteolysis of Membrance-Type 1 Matrix Metalloproteinase |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| ID登録 |
|
|
ID登録 |
10.24517/00027355 |
|
ID登録タイプ |
JaLC |
| 著者 |
Takino, Takahisa
Miyamori, Hisashi
Kawaguchi, Noriko
Uekita, Takamasa
Seiki, Motoharu
Sato, Hiroshi
|
| 著者別表示 |
滝野, 隆久
宮森, 久志
清木, 元治
佐藤, 博
|
| 提供者所属 |
|
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内容記述タイプ |
Other |
|
内容記述 |
金沢大学がん研究所 |
| 書誌情報 |
Biochemical and biophysical research communications
巻 304,
号 1,
p. 160-166,
発行日 2003-04-01
|
| ISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0006-291X |
| DOI |
|
|
関連タイプ |
isVersionOf |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1016/s0006-291x(03)00544-8 |
| 出版者 |
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出版者 |
Elsevier |
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
Membrane-type 1 matrix metalloproteinase (MT1-MMP) is known to be internalized from cell surface, however, the fate of internalized MT1-MMP is still unknown. Here we demonstrate that at least a part of internalized MT1-MMP is targeted for lysosomal proteolysis. Treatment with an inhibitor of lysosomal proteinases chloroquine suppressed degradation of internalized MT1-MMP and induced accumulation of MT1-MMP in CD63-positive lysosomes. Ectopic expression of CD63 accelerated degradation of MT1-MMP, which was blocked by chloroquine. MT1-MMP, and CD63 were shown to form a complex through hemopexin-like domain of MT1-MMP and N-terminal region of CD63, and thus accelerated degradation of MT1-MMP was not observed with mutants lacking these domains. CD63 mutant lacking lysosomal targeting motif was unable to promote MT1-MMP degradation. These results suggest that CD63 regulates MT1-MMP by targeting to lysosomes. |
| 著者版フラグ |
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|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 関連URI |
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識別子タイプ |
URI |
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|
関連識別子 |
http://www.elsevier.com/locate/issn/0006291X |
![CA-PR-TAKINO-T-Takino[1].BBRC.pdf](/static/images/icon/icon_16_pdf.jpg){kind=icon}
CA-PR-TAKINO-T-Takino[1].BBRC.pdf (420.1 kB)
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