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Tetraspanin CD63 Promotes Targetion and Lysosomal Proteolysis of Membrance-Type 1 Matrix Metalloproteinase
https://doi.org/10.24517/00027355
https://doi.org/10.24517/000273556d3ac0cc-9b1d-43bc-804d-b22e15ee2507
| 名前 / ファイル | ライセンス | アクション |
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![CA-PR-TAKINO-T-Takino[1].BBRC.pdf](/static/images/icon/icon_16_pdf.jpg){kind=icon}
CA-PR-TAKINO-T-Takino[1].BBRC.pdf (420.1 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||
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| 公開日 | 2017-10-05 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Tetraspanin CD63 Promotes Targetion and Lysosomal Proteolysis of Membrance-Type 1 Matrix Metalloproteinase | |||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
| 資源タイプ | journal article | |||||||||||||
| ID登録 | ||||||||||||||
| ID登録 | 10.24517/00027355 | |||||||||||||
| ID登録タイプ | JaLC | |||||||||||||
| 著者 |
Takino, Takahisa
× Takino, Takahisa× Miyamori, Hisashi× Kawaguchi, Noriko× Uekita, Takamasa× Seiki, Motoharu× Sato, Hiroshi |
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| 著者別表示 |
滝野, 隆久
× 滝野, 隆久
× 宮森, 久志
× 清木, 元治
× 佐藤, 博
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| 提供者所属 | ||||||||||||||
| 内容記述タイプ | Other | |||||||||||||
| 内容記述 | 金沢大学がん研究所 | |||||||||||||
| 書誌情報 |
Biochemical and biophysical research communications 巻 304, 号 1, p. 160-166, 発行日 2003-04-01 |
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| ISSN | ||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||
| 収録物識別子 | 0006-291X | |||||||||||||
| DOI | ||||||||||||||
| 関連タイプ | isVersionOf | |||||||||||||
| 識別子タイプ | DOI | |||||||||||||
| 関連識別子 | https://doi.org/10.1016/s0006-291x(03)00544-8 | |||||||||||||
| 出版者 | ||||||||||||||
| 出版者 | Elsevier | |||||||||||||
| 抄録 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Membrane-type 1 matrix metalloproteinase (MT1-MMP) is known to be internalized from cell surface, however, the fate of internalized MT1-MMP is still unknown. Here we demonstrate that at least a part of internalized MT1-MMP is targeted for lysosomal proteolysis. Treatment with an inhibitor of lysosomal proteinases chloroquine suppressed degradation of internalized MT1-MMP and induced accumulation of MT1-MMP in CD63-positive lysosomes. Ectopic expression of CD63 accelerated degradation of MT1-MMP, which was blocked by chloroquine. MT1-MMP, and CD63 were shown to form a complex through hemopexin-like domain of MT1-MMP and N-terminal region of CD63, and thus accelerated degradation of MT1-MMP was not observed with mutants lacking these domains. CD63 mutant lacking lysosomal targeting motif was unable to promote MT1-MMP degradation. These results suggest that CD63 regulates MT1-MMP by targeting to lysosomes. | |||||||||||||
| 著者版フラグ | ||||||||||||||
| 出版タイプ | AM | |||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||
| 関連URI | ||||||||||||||
| 識別子タイプ | URI | |||||||||||||
| 関連識別子 | http://www.elsevier.com/locate/issn/0006291X | |||||||||||||
