{"created":"2023-07-27T06:39:04.235301+00:00","id":27373,"links":{},"metadata":{"_buckets":{"deposit":"b440d7a0-d905-4dcb-90ae-b5819396cd7e"},"_deposit":{"created_by":3,"id":"27373","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"27373"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00027373","sets":["1777:1778:1779"]},"author_link":["47488","142","47489","74","47493","47491","47490","47492","47487"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1996-06-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageEnd":"2439","bibliographicPageStart":"2433","bibliographicVolumeNumber":"97","bibliographic_titles":[{"bibliographic_title":"Journal of Clinical Investigation"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"FK506 is a powerful immunosuppressive drug currently in use that inhibits the activation of several transcription factors (nuclear factor (NF)-AT and NF-κB) critical for T cell activation. We show here that, contrary to the situation in T cells, FK506 activates transcription factor NF-κB in non-lymphoid cells such as fibroblasts and renal mesangial cells. We further show that FK506 induces NF-κB-regulated IL-6 production in vitro and in vivo, in particular in kidney. IL-6 has been shown previously to produce renal abnormalities in vivo, such as mesangioproliferative glomerulonephritis. Similar renal abnormalities were also observed in FK506-treated animals. These results thus suggest a causal relationship between FK506-induced NF-κB activation/IL-6 production and some of FK506-induced renal abnormalities.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学がん研究所がん分子細胞制御","subitem_description_type":"Other"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"American Society for Clinical Investigation"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1172/jci118690","subitem_relation_type_select":"DOI"}}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA00695520","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0021-9738","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Muraoka, Kei-ichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fujimoto, Koutaro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sun, Xiangao"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshioka, Katsuji"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Shimizu, Kou-ichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yagi, Masao"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Bose, Jr. Henry"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyazaki, Itsuo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamamoto, Ken-ichi"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"CA-PR-YOSHIOKA-K-2433.pdf","filesize":[{"value":"529.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"CA-PR-YOSHIOKA-K-2433.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/27373/files/CA-PR-YOSHIOKA-K-2433.pdf"},"version_id":"04a8b288-c69c-477c-9ff5-36e8afbbe404"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Immunosuppressant FK506 induces interleukin-6 production through the activation of transcription factor nuclear factor (NF)-κB implications for FK506 nephropathy","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Immunosuppressant FK506 induces interleukin-6 production through the activation of transcription factor nuclear factor (NF)-κB implications for FK506 nephropathy"}]},"item_type_id":"4","owner":"3","path":["1779"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"27373","relation_version_is_last":true,"title":["Immunosuppressant FK506 induces interleukin-6 production through the activation of transcription factor nuclear factor (NF)-κB implications for FK506 nephropathy"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T12:22:22.681294+00:00"}