@article{oai:kanazawa-u.repo.nii.ac.jp:00027375,
 author = {Li, Yingzhu and Shimizu, Hiroko and Xiang, Shuang-Lin and Maru, Yoshiro and Takao, Noriaki and Yamamoto, Ken-ichi},
 issue = {5},
 journal = {Biochemical and biophysical research communications},
 month = {Dec},
 note = {c-Abl plays important roles in cellular response to DNA damage. However, possible roles for Arg (Abl-related gene) in DNA damage response are unknown. Here, we show that ionizing radiation (IR)-induced Rad51 focus formation is reduced in Arg-deficient cells generated from a chicken B cell line by targeted disruption. This is consistent with the findings that Arg-deficient cells display hypersensitivity to IR, elevated frequencies of IR-induced chromosomal aberrations, and reduced targeted integration frequencies. All of these abnormalities in DNA damage repair are also observed in ATM-deficient cells but not in c-Abl-deficient cells. Finally, we show that Arg interacts with and phosphorylates Rad51 in 293T cells. These results suggest that Arg plays a role in homologous recombinational (HR) DNA repair by phosphorylating Rad51., 金沢大学がん研究所},
 pages = {697--702},
 title = {Arg tyrosine kinase is involved in homologous recombinational DNA repair},
 volume = {299},
 year = {2002}
}