{"created":"2023-07-27T06:39:04.321789+00:00","id":27375,"links":{},"metadata":{"_buckets":{"deposit":"af7b6a40-a864-4dae-8be1-5c782cc37e2d"},"_deposit":{"created_by":3,"id":"27375","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"27375"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00027375","sets":["1777:1778:1779"]},"author_link":["47500","94","47499","47498","74","47501"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002-12-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"702","bibliographicPageStart":"697","bibliographicVolumeNumber":"299","bibliographic_titles":[{"bibliographic_title":"Biochemical and biophysical research communications"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"c-Abl plays important roles in cellular response to DNA damage. However, possible roles for Arg (Abl-related gene) in DNA damage response are unknown. Here, we show that ionizing radiation (IR)-induced Rad51 focus formation is reduced in Arg-deficient cells generated from a chicken B cell line by targeted disruption. This is consistent with the findings that Arg-deficient cells display hypersensitivity to IR, elevated frequencies of IR-induced chromosomal aberrations, and reduced targeted integration frequencies. All of these abnormalities in DNA damage repair are also observed in ATM-deficient cells but not in c-Abl-deficient cells. Finally, we show that Arg interacts with and phosphorylates Rad51 in 293T cells. These results suggest that Arg plays a role in homologous recombinational (HR) DNA repair by phosphorylating Rad51.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学がん研究所","subitem_description_type":"Other"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/s0006-291x(02)02692-x","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.elsevier.com/locate/issn/0006291X","subitem_relation_type_select":"URI"}}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0006-291X","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Li, Yingzhu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shimizu, Hiroko"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Xiang, Shuang-Lin"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Maru, Yoshiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takao, Noriaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamamoto, Ken-ichi"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"CA-PR-YAMAMOTO-K-Li et al(BBRC.pdf","filesize":[{"value":"107.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"CA-PR-YAMAMOTO-K-Li et al(BBRC.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/27375/files/CA-PR-YAMAMOTO-K-Li et al(BBRC.pdf"},"version_id":"be4ec0fb-d386-4f57-899e-33b520115044"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Arg tyrosine kinase is involved in homologous recombinational DNA repair","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Arg tyrosine kinase is involved in homologous recombinational DNA repair"}]},"item_type_id":"4","owner":"3","path":["1779"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"27375","relation_version_is_last":true,"title":["Arg tyrosine kinase is involved in homologous recombinational DNA repair"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T12:22:20.877948+00:00"}