{"created":"2023-07-27T06:39:04.364638+00:00","id":27376,"links":{},"metadata":{"_buckets":{"deposit":"cceb4bd8-5c51-47fe-a547-a4010246bb29"},"_deposit":{"created_by":3,"id":"27376","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"27376"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00027376","sets":["1777:1778:1779"]},"author_link":["83","256","47502"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-03-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"2384","bibliographicPageStart":"2376","bibliographicVolumeNumber":"279","bibliographic_titles":[{"bibliographic_title":"FEBS Journal"}]}]},"item_4_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"今村, 龍"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"須田, 貴司"}],"nameIdentifiers":[{},{},{},{}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Despite a dogma that apoptosis does not induce inflammation, Fas ligand (FasL), a well-known death factor, possesses pro-inflammatory activity. For example, FasL induces nuclear factor κB (NF-κB) activity and interleukin 8 (IL-8) production by engagement of Fas in human cells. Here, we found that a dominant negative mutant of c-Jun, a component of the activator protein-1 (AP-1) transcription factor, inhibits FasL-induced AP-1 activity and IL-8 production in HEK293 cells. Selective inhibition of AP-1 did not affect NF-κB activation and vice versa, indicating that their activations were not sequential events. The FasL-induced AP-1 activation could be inhibited by deleting or introducing the lymphoproliferation (lpr)-type point mutation into the Fas death domain (DD), knocking down the Fas-associated DD protein (FADD), abrogating caspase-8 expression with small interfering RNAs, or using inhibitors for pan-caspase and caspase-8 but not caspase-1 or caspase-3. Furthermore, wildtype, but not a catalytically inactive mutant, of caspase-8 reconstituted the FasL-induced AP-1 activation in caspase-8-deficient cells. Fas ligand induced the phosphorylation of two of the three major mitogen-activated protein kinases (MAPKs): extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) but not p38 MAPK. Unexpectedly, an inhibitor for JNK but not for MAPK/ERK kinase inhibited the FasL-induced AP-1 activation and IL-8 production. These results demonstrate that FasL-induced AP-1 activation is required for optimal IL-8 production, and this process is mediated by FADD, caspase-8, and JNK. © 2007 The Authors.","subitem_description_type":"Abstract"}]},"item_4_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00027363","subitem_identifier_reg_type":"JaLC"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Blackwell Publishing"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1111/j.1742-4658.2007.05772.x","subitem_relation_type_select":"DOI"}}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1742-464X","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Matsumoto, Norihiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Imamura, Ryu"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Suda, Takashi"}],"nameIdentifiers":[{},{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"CA-PR-SUDA-T-2376.pdf","filesize":[{"value":"817.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-SUDA-T-2376.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/27376/files/CA-PR-SUDA-T-2376.pdf"},"version_id":"15ebbbb5-2d82-4127-89c7-ed815755db49"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Caspase-8- and JNK-dependent AP-1 activation is required for Fas ligand-induced IL-8 production","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Caspase-8- and JNK-dependent AP-1 activation is required for Fas ligand-induced IL-8 production"}]},"item_type_id":"4","owner":"3","path":["1779"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"27376","relation_version_is_last":true,"title":["Caspase-8- and JNK-dependent AP-1 activation is required for Fas ligand-induced IL-8 production"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T10:50:47.924050+00:00"}