@article{oai:kanazawa-u.repo.nii.ac.jp:00027390,
 author = {Takino, Takahisa and Tsuge, Hisashi and Ozawa, Terumasa and Sato, Hiroshi},
 issue = {4},
 journal = {Biochemical and Biophysical Research Communications},
 month = {Jun},
 note = {Membrane-type 1 matrix metalloproteinase (MT1-MMP) is essential for tumor invasion and growth. We show here that MT1-MMP induces extracellular signal-regulated kinase (ERK) activation in cancer cells cultured in collagen gel, which is indispensable for their proliferation. Inhibition of MT1-MMP by MMP inhibitor or small interfering RNA suppressed activation of focal adhesion kinase (FAK) and ERK in MT1-MMP-expressing cancer cells, which resulted in up-regulation of p21WAF1 and suppression of cell growth in collagen gel. Cell proliferation was also abrogated by the inhibitor against ERK pathway without affecting FAK phosphorylation. MT1-MMP and integrin αvβ3 were shown to be involved in c-Src activation, which induced FAK and ERK activation in collagen gel. These MT1-MMP-mediated signal transductions were paxillin dependent, as knockdown of paxillin reduced cell growth and ERK activation, and co-expression of MT1-MMP with paxillin induced ERK activation. The results suggest that MT1-MMP contributes to proliferation of cancer cells in the extracellular matrix by activating ERK through c-Src and paxillin. © 2010 Elsevier Inc. All rights reserved., 金沢大学がん研究所},
 pages = {1042--1047},
 title = {MT1-MMP promotes cell growth and ERK activation through c-Src and paxillin in three-dimensional collagen matrix},
 volume = {396},
 year = {2010}
}